Journal Article

DKFZ-2023-01422

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response.

Zhang, L.DKFZ* ; Wirth, M.DKFZ* ; Patra, U. ; Stroh, J.DKFZ* ; Isaakidis, K.DKFZ* ; Rieger, L. ; Kossatz, S.DKFZ* ; Milanovic, M.DKFZ* ; Zang, C.DKFZ* ; Demel, U.DKFZ* ; Keiten-Schmitz, J.DKFZ* ; Wagner, K.DKFZ* ; Steiger, K.DKFZ* ; Rad, R.DKFZ* ; Bassermann, F.DKFZ* ; Müller, S.DKFZ* ; Keller, U.DKFZ* ; Schick, M.DKFZ*

2023
EMBO Press Heidelberg

This record in other databases:  

Please use a persistent id in citations: doi:10.15252/emmm.202216431

Abstract: The DNA damage response (DDR) acts as a barrier to malignant transformation and is often impaired during tumorigenesis. Exploiting the impaired DDR can be a promising therapeutic strategy; however, the mechanisms of inactivation and corresponding biomarkers are incompletely understood. Starting from an unbiased screening approach, we identified the SMC5-SMC6 Complex Localization Factor 2 (SLF2) as a regulator of the DDR and biomarker for a B-cell lymphoma (BCL) patient subgroup with an adverse prognosis. SLF2-deficiency leads to loss of DDR factors including Claspin (CLSPN) and consequently impairs CHK1 activation. In line with this mechanism, genetic deletion of Slf2 drives lymphomagenesis in vivo. Tumor cells lacking SLF2 are characterized by a high level of DNA damage, which leads to alterations of the post-translational SUMOylation pathway as a safeguard. The resulting co-dependency confers synthetic lethality to a clinically applicable SUMOylation inhibitor (SUMOi), and inhibitors of the DDR pathway act highly synergistic with SUMOi. Together, our results identify SLF2 as a DDR regulator and reveal co-targeting of the DDR and SUMOylation as a promising strategy for treating aggressive lymphoma.

Keyword(s): CHK1 ; DNA damage response ; SLF2 ; SUMO ; lymphoma

Note: 2023 Sep 11;15(9):e16431

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Berlin (BE01)
2. DKTK Koordinierungsstelle Frankfurt (FM01)
3. DKTK Koordinierungsstelle München (MU01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
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