%0 Journal Article
%A Chaves-Filho, Adriano B
%A Schulze, Almut
%T Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy.
%J Cancer cell
%V 41
%N 7
%@ 1535-6108
%C New York, NY
%I Elsevier
%M DKFZ-2023-01452
%P 1204 - 1206
%D 2023
%Z #EA:A410#LA:A410# / Comment / Preview
%X Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell exhaustion by inhibiting mTORC1 signaling. Moreover, they demonstrate that increasing cholesterol levels in chimeric antigen receptor (CAR)-T cells by blocking liver X receptor (LXR) leads to improved anti-tumor function.
%K Humans
%K Receptors, Chimeric Antigen
%K Tumor Microenvironment
%K Immunotherapy, Adoptive
%K Neoplasms: therapy
%K T-Lymphocytes, Cytotoxic
%K Receptors, Chimeric Antigen (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37244258
%R 10.1016/j.ccell.2023.05.013
%U https://inrepo02.dkfz.de/record/277735