Journal Article

DKFZ-2023-01452

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy.

Chaves-Filho, A. B. (First author)DKFZ* ; Schulze, A. (Last author)DKFZ*

2023
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.ccell.2023.05.013

Abstract: Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell exhaustion by inhibiting mTORC1 signaling. Moreover, they demonstrate that increasing cholesterol levels in chimeric antigen receptor (CAR)-T cells by blocking liver X receptor (LXR) leads to improved anti-tumor function.

Keyword(s): Humans (MeSH) ; Receptors, Chimeric Antigen (MeSH) ; Tumor Microenvironment (MeSH) ; Immunotherapy, Adoptive (MeSH) ; Neoplasms: therapy (MeSH) ; T-Lymphocytes, Cytotoxic (MeSH) ; Receptors, Chimeric Antigen

Note: #EA:A410#LA:A410# / Comment / Preview

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Contributing Institute(s):

1. Metabolismus und Microenvironment (A410)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 50 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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