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@ARTICLE{ChavesFilho:277735,
      author       = {A. B. Chaves-Filho$^*$ and A. Schulze$^*$},
      title        = {{C}holesterol atlas of tumor microenvironment provides
                      route to improved {CAR}-{T} therapy.},
      journal      = {Cancer cell},
      volume       = {41},
      number       = {7},
      issn         = {1535-6108},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-01452},
      pages        = {1204 - 1206},
      year         = {2023},
      note         = {#EA:A410#LA:A410# / Comment / Preview},
      abstract     = {Cholesterol is essential for the ability of cytotoxic T
                      cells to eliminate cancer cells. In this issue of Cancer
                      Cell, Yan et al. reveal how intra-tumoral cholesterol
                      deficiency contributes to T cell exhaustion by inhibiting
                      mTORC1 signaling. Moreover, they demonstrate that increasing
                      cholesterol levels in chimeric antigen receptor (CAR)-T
                      cells by blocking liver X receptor (LXR) leads to improved
                      anti-tumor function.},
      keywords     = {Humans / Receptors, Chimeric Antigen / Tumor
                      Microenvironment / Immunotherapy, Adoptive / Neoplasms:
                      therapy / T-Lymphocytes, Cytotoxic / Receptors, Chimeric
                      Antigen (NLM Chemicals)},
      cin          = {A410},
      ddc          = {610},
      cid          = {I:(DE-He78)A410-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37244258},
      doi          = {10.1016/j.ccell.2023.05.013},
      url          = {https://inrepo02.dkfz.de/record/277735},
}