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000277766 1001_ $$aBraulke, Thomas$$b0
000277766 245__ $$aLysosomal enzyme trafficking: from molecular mechanisms to human diseases.
000277766 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2024
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000277766 500__ $$a#LA:A330# / 2024 Mar;34(3):198-210
000277766 520__ $$aLysosomes degrade and recycle macromolecules that are delivered through the biosynthetic, endocytic, and autophagic routes. Hydrolysis of the different classes of macromolecules is catalyzed by about 70 soluble enzymes that are transported from the Golgi apparatus to lysosomes in a mannose 6-phosphate (M6P)-dependent process. The molecular machinery that generates M6P tags for receptor-mediated targeting of lysosomal enzymes was thought to be understood in detail. However, recent studies on the M6P pathway have identified a previously uncharacterized core component, yielded structural insights in known components, and uncovered functions in various human diseases. Here we review molecular mechanisms of lysosomal enzyme trafficking and discuss its relevance for rare lysosomal disorders, cancer, and viral infection.
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000277766 650_7 $$2Other$$acancer metabolism
000277766 650_7 $$2Other$$alysosomal enzymes
000277766 650_7 $$2Other$$alysosomal storage disorders
000277766 650_7 $$2Other$$amannose 6-phosphate pathway
000277766 650_7 $$2Other$$aviral infections
000277766 7001_ $$aCarette, Jan E$$b1
000277766 7001_ $$0P:(DE-He78)c8525dbb77cddc5280375ea4a5e3c13e$$aPalm, Wilhelm$$b2$$eLast author$$udkfz
000277766 773__ $$0PERI:(DE-600)1498903-7$$a10.1016/j.tcb.2023.06.005$$gp. S0962892423001289$$n3$$p198-210$$tTrends in cell biology$$v34$$x0962-8924$$y2024
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