Journal Article (Review Article)

DKFZ-2023-01481

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lysosomal enzyme trafficking: from molecular mechanisms to human diseases.

Braulke, T. ; Carette, J. E. ; Palm, W. (Last author)DKFZ*

2024
Elsevier Science Amsterdam [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.tcb.2023.06.005

Abstract: Lysosomes degrade and recycle macromolecules that are delivered through the biosynthetic, endocytic, and autophagic routes. Hydrolysis of the different classes of macromolecules is catalyzed by about 70 soluble enzymes that are transported from the Golgi apparatus to lysosomes in a mannose 6-phosphate (M6P)-dependent process. The molecular machinery that generates M6P tags for receptor-mediated targeting of lysosomal enzymes was thought to be understood in detail. However, recent studies on the M6P pathway have identified a previously uncharacterized core component, yielded structural insights in known components, and uncovered functions in various human diseases. Here we review molecular mechanisms of lysosomal enzyme trafficking and discuss its relevance for rare lysosomal disorders, cancer, and viral infection.

Keyword(s): LYSET ; cancer metabolism ; lysosomal enzymes ; lysosomal storage disorders ; mannose 6-phosphate pathway ; viral infections

Note: #LA:A330# / 2024 Mar;34(3):198-210

---

Contributing Institute(s):

1. A330 NWG Signaltransduktion und Stoffwechsel der Zelle (A330)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2023

---

Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---