TY  - JOUR
AU  - Braulke, Thomas
AU  - Carette, Jan E
AU  - Palm, Wilhelm
TI  - Lysosomal enzyme trafficking: from molecular mechanisms to human diseases.
JO  - Trends in cell biology
VL  - 34
IS  - 3
SN  - 0962-8924
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2023-01481
SP  - 198-210
PY  - 2024
N1  - #LA:A330# / 2024 Mar;34(3):198-210
AB  - Lysosomes degrade and recycle macromolecules that are delivered through the biosynthetic, endocytic, and autophagic routes. Hydrolysis of the different classes of macromolecules is catalyzed by about 70 soluble enzymes that are transported from the Golgi apparatus to lysosomes in a mannose 6-phosphate (M6P)-dependent process. The molecular machinery that generates M6P tags for receptor-mediated targeting of lysosomal enzymes was thought to be understood in detail. However, recent studies on the M6P pathway have identified a previously uncharacterized core component, yielded structural insights in known components, and uncovered functions in various human diseases. Here we review molecular mechanisms of lysosomal enzyme trafficking and discuss its relevance for rare lysosomal disorders, cancer, and viral infection.
KW  - LYSET (Other)
KW  - cancer metabolism (Other)
KW  - lysosomal enzymes (Other)
KW  - lysosomal storage disorders (Other)
KW  - mannose 6-phosphate pathway (Other)
KW  - viral infections (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37474375
DO  - DOI:10.1016/j.tcb.2023.06.005
UR  - https://inrepo02.dkfz.de/record/277766
ER  -