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@ARTICLE{Braulke:277766,
      author       = {T. Braulke and J. E. Carette and W. Palm$^*$},
      title        = {{L}ysosomal enzyme trafficking: from molecular mechanisms
                      to human diseases.},
      journal      = {Trends in cell biology},
      volume       = {34},
      number       = {3},
      issn         = {0962-8924},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-01481},
      pages        = {198-210},
      year         = {2024},
      note         = {#LA:A330# / 2024 Mar;34(3):198-210},
      abstract     = {Lysosomes degrade and recycle macromolecules that are
                      delivered through the biosynthetic, endocytic, and
                      autophagic routes. Hydrolysis of the different classes of
                      macromolecules is catalyzed by about 70 soluble enzymes that
                      are transported from the Golgi apparatus to lysosomes in a
                      mannose 6-phosphate (M6P)-dependent process. The molecular
                      machinery that generates M6P tags for receptor-mediated
                      targeting of lysosomal enzymes was thought to be understood
                      in detail. However, recent studies on the M6P pathway have
                      identified a previously uncharacterized core component,
                      yielded structural insights in known components, and
                      uncovered functions in various human diseases. Here we
                      review molecular mechanisms of lysosomal enzyme trafficking
                      and discuss its relevance for rare lysosomal disorders,
                      cancer, and viral infection.},
      subtyp        = {Review Article},
      keywords     = {LYSET (Other) / cancer metabolism (Other) / lysosomal
                      enzymes (Other) / lysosomal storage disorders (Other) /
                      mannose 6-phosphate pathway (Other) / viral infections
                      (Other)},
      cin          = {A330},
      ddc          = {570},
      cid          = {I:(DE-He78)A330-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37474375},
      doi          = {10.1016/j.tcb.2023.06.005},
      url          = {https://inrepo02.dkfz.de/record/277766},
}