guest ::
| Home > Publications database > Lysosomal enzyme trafficking: from molecular mechanisms to human diseases. > print |
| Home > Publications database > Lysosomal enzyme trafficking: from molecular mechanisms to human diseases. > print |
| 001 | 277766 | ||
| 005 | 20240311134955.0 | ||
| 024 | 7 | _ | |a 10.1016/j.tcb.2023.06.005 |2 doi |
| 024 | 7 | _ | |a pmid:37474375 |2 pmid |
| 024 | 7 | _ | |a 0962-8924 |2 ISSN |
| 024 | 7 | _ | |a 1879-3088 |2 ISSN |
| 024 | 7 | _ | |a altmetric:151684167 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2023-01481 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Braulke, Thomas |b 0 |
| 245 | _ | _ | |a Lysosomal enzyme trafficking: from molecular mechanisms to human diseases. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2024 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1710161336_7414 |2 PUB:(DE-HGF) |x Review Article |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #LA:A330# / 2024 Mar;34(3):198-210 |
| 520 | _ | _ | |a Lysosomes degrade and recycle macromolecules that are delivered through the biosynthetic, endocytic, and autophagic routes. Hydrolysis of the different classes of macromolecules is catalyzed by about 70 soluble enzymes that are transported from the Golgi apparatus to lysosomes in a mannose 6-phosphate (M6P)-dependent process. The molecular machinery that generates M6P tags for receptor-mediated targeting of lysosomal enzymes was thought to be understood in detail. However, recent studies on the M6P pathway have identified a previously uncharacterized core component, yielded structural insights in known components, and uncovered functions in various human diseases. Here we review molecular mechanisms of lysosomal enzyme trafficking and discuss its relevance for rare lysosomal disorders, cancer, and viral infection. |
| 536 | _ | _ | |a 311 - Zellbiologie und Tumorbiologie (POF4-311) |0 G:(DE-HGF)POF4-311 |c POF4-311 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a LYSET |2 Other |
| 650 | _ | 7 | |a cancer metabolism |2 Other |
| 650 | _ | 7 | |a lysosomal enzymes |2 Other |
| 650 | _ | 7 | |a lysosomal storage disorders |2 Other |
| 650 | _ | 7 | |a mannose 6-phosphate pathway |2 Other |
| 650 | _ | 7 | |a viral infections |2 Other |
| 700 | 1 | _ | |a Carette, Jan E |b 1 |
| 700 | 1 | _ | |a Palm, Wilhelm |0 P:(DE-He78)c8525dbb77cddc5280375ea4a5e3c13e |b 2 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.tcb.2023.06.005 |g p. S0962892423001289 |0 PERI:(DE-600)1498903-7 |n 3 |p 198-210 |t Trends in cell biology |v 34 |y 2024 |x 0962-8924 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:277766 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)c8525dbb77cddc5280375ea4a5e3c13e |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-311 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Zellbiologie und Tumorbiologie |x 0 |
| 914 | 1 | _ | |y 2023 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2022-11-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2022-11-24 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2023-08-25 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1120 |2 StatID |b BIOSIS Reviews Reports And Meetings |d 2023-08-25 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b TRENDS CELL BIOL : 2022 |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-08-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2023-08-25 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-08-25 |
| 915 | _ | _ | |a IF >= 15 |0 StatID:(DE-HGF)9915 |2 StatID |b TRENDS CELL BIOL : 2022 |d 2023-08-25 |
| 920 | 2 | _ | |0 I:(DE-He78)A330-20160331 |k A330 |l A330 NWG Signaltransduktion und Stoffwechsel der Zelle |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)A330-20160331 |k A330 |l A330 NWG Signaltransduktion und Stoffwechsel der Zelle |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)A330-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|