TY  - JOUR
AU  - Amaya Ramirez, Cinthia Claudia
AU  - Loayza-Puch, Fabricio
TI  - Breast Cancer Metastatic Progression Requires mRNA Posttranscriptional Suppression.
JO  - Cancer research
VL  - 83
IS  - 15
SN  - 0099-7013
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2023-01485
SP  - 2448-2449
PY  - 2023
N1  - #EA:B250#LA:B250# / 2023 Aug 1;83(15):2448-2449 / IN THE SPOTLIGHT
AB  - Cancer cell survival is highly dependent on its metabolic reprogramming, which supports not only cell growth but also confers to the tumor cells characteristics to initiate migration and colonization. Among the different mechanisms that are involved, translational control plays a significant role in oncogenesis; however, its impact on cancer progression still remains poorly understood. A study by Navickas and colleagues revealed that the RNA-binding protein heterogeneous nuclear ribonucleoprotein C (HNRNPC) functions as a translational regulator, and its downregulation in highly metastatic cells leads to the lengthening of 3' untranslated regions in HNRNPC-bound mRNAs, resulting in translational repression mediated by the AGO-miRNA RNA-induced silencing complex.
LB  - PUB:(DE-HGF)16
C6  - pmid:37470809
DO  - DOI:10.1158/0008-5472.CAN-23-1729
UR  - https://inrepo02.dkfz.de/record/277770
ER  -