Journal Article

DKFZ-2023-01485

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Breast Cancer Metastatic Progression Requires mRNA Posttranscriptional Suppression.

Amaya Ramirez, C. C. (First author)DKFZ* ; Loayza-Puch, F. (Last author)DKFZ*

2023
AACR Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/0008-5472.CAN-23-1729

Abstract: Cancer cell survival is highly dependent on its metabolic reprogramming, which supports not only cell growth but also confers to the tumor cells characteristics to initiate migration and colonization. Among the different mechanisms that are involved, translational control plays a significant role in oncogenesis; however, its impact on cancer progression still remains poorly understood. A study by Navickas and colleagues revealed that the RNA-binding protein heterogeneous nuclear ribonucleoprotein C (HNRNPC) functions as a translational regulator, and its downregulation in highly metastatic cells leads to the lengthening of 3' untranslated regions in HNRNPC-bound mRNAs, resulting in translational repression mediated by the AGO-miRNA RNA-induced silencing complex.

Note: #EA:B250#LA:B250# / 2023 Aug 1;83(15):2448-2449 / IN THE SPOTLIGHT

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Contributing Institute(s):

1. B250 NWG Translationskontrolle und Stoffwechsel (B250)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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