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@ARTICLE{Farin:277774,
      author       = {H. Farin$^*$ and M. H. Mosa and B. Ndreshkjana and B. M.
                      Grebbin and B. Ritter and C. Menche and K. B. Kennel and P.
                      K. Ziegler and L. Szabo and J. Bollrath and D. Rieder and B.
                      E. Michels and A. Kress and M. Bozlar and T. Darvishi and S.
                      Stier and I.-M. Kur and K. Bankov and R. Kesselring$^*$ and
                      S. Fichtner-Feigl and B. Brune$^*$ and T. O. Goetze and
                      S.-E. Al-Batran and C. H. Brandts$^*$ and W. O. Bechstein
                      and P. J. Wild$^*$ and A. Weigert$^*$ and S. Muller and S.
                      Knapp$^*$ and Z. Trajanoski and F. R. Greten$^*$},
      title        = {{C}olorectal cancer organoid-stroma biobank allows
                      subtype-specific assessment of individualized therapy
                      responses.},
      journal      = {Cancer discovery},
      volume       = {13},
      number       = {10},
      issn         = {2159-8274},
      address      = {Philadelphia, Pa.},
      reportid     = {DKFZ-2023-01489},
      pages        = {2192-2211},
      year         = {2023},
      note         = {2023 Oct 5;13(10):2192-2211},
      abstract     = {In colorectal cancers (CRC) the tumor microenvironment
                      plays a key role for prognosis and therapy efficacy.
                      Patient-derived tumor organoids (PDTOs) show enormous
                      potential for preclinical testing, however, cultured tumor
                      cells lose important characteristics including the
                      'consensus molecular subtypes' (CMS). To better reflect the
                      cellular heterogeneity, we established the CRC
                      organoid-stroma biobank of matched PDTOs and
                      cancer-associated fibroblasts (CAFs) from 30 patients.
                      Context-specific phenotyping showed that xenotransplantation
                      or co-culture with CAFs improves the transcriptomic fidelity
                      and instructs subtype-specific stromal gene expression.
                      Furthermore, functional profiling in co-culture exposed
                      CMS4-specific therapeutic resistance to Gefitinib and SN-38
                      and prognostic expression signatures. Chemogenomic library
                      screening identified patient- and therapy-dependent
                      mechanisms of stromal resistance including MET as common
                      target. Our results demonstrate that CRC phenotypes are
                      encrypted in the cancer epithelium in a plastic fashion that
                      strongly depends on the context. Consequently, CAFs are
                      essential for faithful representation of molecular subtypes
                      and therapy responses ex vivo.},
      cin          = {FM01 / FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331 / I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37489084},
      doi          = {10.1158/2159-8290.CD-23-0050},
      url          = {https://inrepo02.dkfz.de/record/277774},
}