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000277948 1001_ $$aRubio-Lara, Juan A$$b0
000277948 245__ $$aExpanding hematopoietic stem cell ex vivo: recent advances and technical considerations.
000277948 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
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000277948 500__ $$a#EA:A011#LA:A010# / Volumes 125–126, September–October 2023, Pages 6-15 / Perspective
000277948 520__ $$aHematopoietic stem cells (HSCs) are the most primitive cell type in the hematopoietic hierarchy, which are responsible for sustaining the lifelong production of mature blood and immune cells. Due to their superior long-term regenerative capacity, HSC therapies such as stem cell transplantation have been used in a broad range of hematological disorders. However, the rarity of this population in vivo considerably limits its clinical applications and large-scale analyses such as screening and safety studies. Therefore, ex vivo culture methods that allow long-term expansion and maintenance of functional HSCs are instrumental to overcome difficulties in studying HSC biology and improving HSC therapies. In this perspective, we discuss recent advances and technical considerations for three ex vivo HSC expansion methods including 1) polyvinyl alcohol-based HSC expansion, 2) mesenchymal stromal cell-HSC co-culture, and 3) 2D/3D hydrogel HSC culture. This review summarizes the presentations and discussions from the 2022 International Society for Experimental Hematology (ISEH) Annual Meeting New Investigator Technology Session.
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000277948 7001_ $$aIgarashi, Kyomi J$$b1
000277948 7001_ $$0P:(DE-He78)dbe2fd9578ec0bf59e0e17592b04f22f$$aSood, Shubhankar$$b2$$eFirst author$$udkfz
000277948 7001_ $$aJohansson, Alban$$b3
000277948 7001_ $$aSommerkamp, Pia$$b4
000277948 7001_ $$aYamashita, Masayuki$$b5
000277948 7001_ $$0P:(DE-HGF)0$$aLin, Dawn S$$b6$$eLast author
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