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@ARTICLE{RubioLara:277948,
      author       = {J. A. Rubio-Lara and K. J. Igarashi and S. Sood$^*$ and A.
                      Johansson and P. Sommerkamp and M. Yamashita and D. S.
                      Lin$^*$},
      title        = {{E}xpanding hematopoietic stem cell ex vivo: recent
                      advances and technical considerations.},
      journal      = {Experimental hematology},
      volume       = {125–126},
      number       = {September–October},
      issn         = {0531-5573},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-01591},
      pages        = {6-11},
      year         = {2023},
      note         = {#EA:A011#LA:A010# / Volumes 125–126, September–October
                      2023, Pages 6-15 / Perspective},
      abstract     = {Hematopoietic stem cells (HSCs) are the most primitive cell
                      type in the hematopoietic hierarchy, which are responsible
                      for sustaining the lifelong production of mature blood and
                      immune cells. Due to their superior long-term regenerative
                      capacity, HSC therapies such as stem cell transplantation
                      have been used in a broad range of hematological disorders.
                      However, the rarity of this population in vivo considerably
                      limits its clinical applications and large-scale analyses
                      such as screening and safety studies. Therefore, ex vivo
                      culture methods that allow long-term expansion and
                      maintenance of functional HSCs are instrumental to overcome
                      difficulties in studying HSC biology and improving HSC
                      therapies. In this perspective, we discuss recent advances
                      and technical considerations for three ex vivo HSC expansion
                      methods including 1) polyvinyl alcohol-based HSC expansion,
                      2) mesenchymal stromal cell-HSC co-culture, and 3) 2D/3D
                      hydrogel HSC culture. This review summarizes the
                      presentations and discussions from the 2022 International
                      Society for Experimental Hematology (ISEH) Annual Meeting
                      New Investigator Technology Session.},
      subtyp        = {Review Article},
      cin          = {A011 / A010},
      ddc          = {610},
      cid          = {I:(DE-He78)A011-20160331 / I:(DE-He78)A010-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37543237},
      doi          = {10.1016/j.exphem.2023.07.006},
      url          = {https://inrepo02.dkfz.de/record/277948},
}