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000278371 1001_ $$0P:(DE-He78)ab36c38b48e62919a71022ba71822570$$aMiddha, Pooja$$b0$$eFirst author
000278371 245__ $$aA genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry.
000278371 260__ $$aLondon$$bBioMed Central$$c2023
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000278371 520__ $$aGenome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94).Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.
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000278371 650_7 $$2Other$$aBreast cancer
000278371 650_7 $$2Other$$aEuropean ancestry
000278371 650_7 $$2Other$$aGene-environment interactions
000278371 650_7 $$2Other$$aGenetic epidemiology
000278371 7001_ $$aWang, Xiaoliang$$b1
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000278371 7001_ $$aBolla, Manjeet K$$b3
000278371 7001_ $$aWang, Qin$$b4
000278371 7001_ $$aDennis, Joe$$b5
000278371 7001_ $$aMichailidou, Kyriaki$$b6
000278371 7001_ $$aAhearn, Thomas U$$b7
000278371 7001_ $$aAndrulis, Irene L$$b8
000278371 7001_ $$aAnton-Culver, Hoda$$b9
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000278371 7001_ $$aBenitez, Javier$$b18
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000278371 7001_ $$aBrooks-Wilson, Angela$$b22
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000278371 7001_ $$aCastelao, Jose E$$b26
000278371 7001_ $$aChanock, Stephen J$$b27
000278371 7001_ $$aChenevix-Trench, Georgia$$b28
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000278371 7001_ $$aCordina-Duverger, Emilie$$b30
000278371 7001_ $$aCouch, Fergus J$$b31
000278371 7001_ $$aCox, Angela$$b32
000278371 7001_ $$aCross, Simon S$$b33
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000278371 7001_ $$aHolleczek, Bernd$$b57
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000278371 7001_ $$aHowell, Anthony$$b61
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000278371 7001_ $$aIngvar, Christian$$b63
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000278371 7001_ $$aInvestigators, kConFab$$b65$$eCollaboration Author
000278371 7001_ $$aIsaksson, Karolin$$b66
000278371 7001_ $$aJernström, Helena$$b67
000278371 7001_ $$aJohn, Esther M$$b68
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000278371 7001_ $$aLarson, Nicole L$$b78
000278371 7001_ $$aLarsson, Susanna$$b79
000278371 7001_ $$aLe Marchand, Loic$$b80
000278371 7001_ $$aLejbkowicz, Flavio$$b81
000278371 7001_ $$aLi, Shuai$$b82
000278371 7001_ $$aLinet, Martha$$b83
000278371 7001_ $$aLissowska, Jolanta$$b84
000278371 7001_ $$aMartinez, Maria Elena$$b85
000278371 7001_ $$aMaurer, Tabea$$b86
000278371 7001_ $$aMulligan, Anna Marie$$b87
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000278371 7001_ $$aRuddy, Kathryn J$$b101
000278371 7001_ $$aSandler, Dale P$$b102
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000278371 7001_ $$aShah, Mitul$$b104
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000278371 7001_ $$aTamimi, Rulla M$$b109
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000278371 7001_ $$aTeras, Lauren R$$b111
000278371 7001_ $$aTomczyk, Katarzyna$$b112
000278371 7001_ $$aTroester, Melissa A$$b113
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000278371 7001_ $$aVachon, Celine M$$b115
000278371 7001_ $$aWang, Sophia S$$b116
000278371 7001_ $$aWeinberg, Clarice R$$b117
000278371 7001_ $$aWildiers, Hans$$b118
000278371 7001_ $$aWillett, Walter$$b119
000278371 7001_ $$aWinham, Stacey J$$b120
000278371 7001_ $$aWolk, Alicja$$b121
000278371 7001_ $$aYang, Xiaohong R$$b122
000278371 7001_ $$aZamora, M Pilar$$b123
000278371 7001_ $$aZheng, Wei$$b124
000278371 7001_ $$aZiogas, Argyrios$$b125
000278371 7001_ $$aDunning, Alison M$$b126
000278371 7001_ $$aPharoah, Paul D P$$b127
000278371 7001_ $$aGarcía-Closas, Montserrat$$b128
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