Journal Article

DKFZ-2023-01621

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry.

Middha, P. (First author)DKFZ* ; Wang, X. ; Behrens, S.DKFZ* ; Bolla, M. K. ; Wang, Q. ; Dennis, J. ; Michailidou, K. ; Ahearn, T. U. ; Andrulis, I. L. ; Anton-Culver, H. ; Arndt, V.DKFZ* ; Aronson, K. J. ; Auer, P. L. ; Augustinsson, A. ; Baert, T. ; Freeman, L. E. B. ; Becher, H. ; Beckmann, M. W. ; Benitez, J. ; Bojesen, S. E. ; Brauch, H. ; Brenner, H.DKFZ* ; Brooks-Wilson, A. ; Campa, D.DKFZ* ; Canzian, F.DKFZ* ; Carracedo, A. ; Castelao, J. E. ; Chanock, S. J. ; Chenevix-Trench, G. ; Consortium, C. (Collaboration Author) ; Cordina-Duverger, E. ; Couch, F. J. ; Cox, A. ; Cross, S. S. ; Czene, K. ; Dossus, L. ; Dugué, P.-A. ; Eliassen, A. H. ; Eriksson, M. ; Evans, D. G. ; Fasching, P. A. ; Figueroa, J. D. ; Fletcher, O. ; Flyger, H. ; Gabrielson, M. ; Gago-Dominguez, M. ; Giles, G. G. ; González-Neira, A. ; Grassmann, F. ; Grundy, A. ; Guénel, P. ; Haiman, C. A. ; Håkansson, N. ; Hall, P. ; Hamann, U.DKFZ* ; Hankinson, S. E. ; Harkness, E. F. ; Holleczek, B. ; Hoppe, R. ; Hopper, J. L. ; Houlston, R. S. ; Howell, A. ; Hunter, D. J. ; Ingvar, C. ; Investigators, A. (Collaboration Author) ; Investigators, k. (Collaboration Author) ; Isaksson, K. ; Jernström, H. ; John, E. M. ; Jones, M. E. ; Kaaks, R.DKFZ* ; Keeman, R. ; Kitahara, C. M. ; Ko, Y.-D. ; Koutros, S. ; Kurian, A. W. ; Lacey, J. V. ; Lambrechts, D. ; Larson, N. L. ; Larsson, S. ; Le Marchand, L. ; Lejbkowicz, F. ; Li, S. ; Linet, M. ; Lissowska, J. ; Martinez, M. E. ; Maurer, T. ; Mulligan, A. M. ; Mulot, C. ; Murphy, R. A. ; Newman, W. G. ; Nielsen, S. F. ; Nordestgaard, B. G. ; Norman, A. ; O'Brien, K. M. ; Olson, J. E. ; Patel, A. V. ; Prentice, R. ; Rees-Punia, E. ; Rennert, G. ; Rhenius, V. ; Ruddy, K. J. ; Sandler, D. P. ; Scott, C. G. ; Shah, M. ; Shu, X.-O. ; Smeets, A. ; Southey, M. C. ; Stone, J. ; Tamimi, R. M. ; Taylor, J. A. ; Teras, L. R. ; Tomczyk, K. ; Troester, M. A. ; Truong, T. ; Vachon, C. M. ; Wang, S. S. ; Weinberg, C. R. ; Wildiers, H. ; Willett, W. ; Winham, S. J. ; Wolk, A. ; Yang, X. R. ; Zamora, M. P. ; Zheng, W. ; Ziogas, A. ; Dunning, A. M. ; Pharoah, P. D. P. ; García-Closas, M. ; Schmidt, M. K. ; Kraft, P. ; Milne, R. L. ; Lindström, S. ; Easton, D. F. ; Chang-Claude, J. (Last author)DKFZ*

2023
BioMed Central London

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Please use a persistent id in citations: doi:10.1186/s13058-023-01691-8

Abstract: Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94).Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.

Keyword(s): Breast cancer ; European ancestry ; Gene-environment interactions ; Genetic epidemiology

Note: #EA:C020#LA:C020#

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C070 Klinische Epidemiologie und Alternf. (C070)
3. Präventive Onkologie (C120)
4. DKTK HD zentral (HD01)
5. C055 Genomische Epidemiologie (C055)
6. Molekulargenetik des Mammakarzinoms (B072)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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