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| 001 | 278371 | ||
| 005 | 20240229155031.0 | ||
| 024 | 7 | _ | |a 10.1186/s13058-023-01691-8 |2 doi |
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| 037 | _ | _ | |a DKFZ-2023-01621 |
| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Middha, Pooja |0 P:(DE-He78)ab36c38b48e62919a71022ba71822570 |b 0 |e First author |
| 245 | _ | _ | |a A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. |
| 260 | _ | _ | |a London |c 2023 |b BioMed Central |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1691673968_941 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:C020#LA:C020# |
| 520 | _ | _ | |a Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94).Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer. |
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| 650 | _ | 7 | |a Breast cancer |2 Other |
| 650 | _ | 7 | |a European ancestry |2 Other |
| 650 | _ | 7 | |a Gene-environment interactions |2 Other |
| 650 | _ | 7 | |a Genetic epidemiology |2 Other |
| 700 | 1 | _ | |a Wang, Xiaoliang |b 1 |
| 700 | 1 | _ | |a Behrens, Sabine |0 P:(DE-He78)6b04712f3afe72044d496a25505cb1ea |b 2 |u dkfz |
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| 700 | 1 | _ | |a Wang, Qin |b 4 |
| 700 | 1 | _ | |a Dennis, Joe |b 5 |
| 700 | 1 | _ | |a Michailidou, Kyriaki |b 6 |
| 700 | 1 | _ | |a Ahearn, Thomas U |b 7 |
| 700 | 1 | _ | |a Andrulis, Irene L |b 8 |
| 700 | 1 | _ | |a Anton-Culver, Hoda |b 9 |
| 700 | 1 | _ | |a Arndt, Volker |0 P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0 |b 10 |u dkfz |
| 700 | 1 | _ | |a Aronson, Kristan J |b 11 |
| 700 | 1 | _ | |a Auer, Paul L |b 12 |
| 700 | 1 | _ | |a Augustinsson, Annelie |b 13 |
| 700 | 1 | _ | |a Baert, Thaïs |b 14 |
| 700 | 1 | _ | |a Freeman, Laura E Beane |b 15 |
| 700 | 1 | _ | |a Becher, Heiko |b 16 |
| 700 | 1 | _ | |a Beckmann, Matthias W |b 17 |
| 700 | 1 | _ | |a Benitez, Javier |b 18 |
| 700 | 1 | _ | |a Bojesen, Stig E |b 19 |
| 700 | 1 | _ | |a Brauch, Hiltrud |b 20 |
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| 700 | 1 | _ | |a Brooks-Wilson, Angela |b 22 |
| 700 | 1 | _ | |a Campa, Daniele |0 P:(DE-HGF)0 |b 23 |
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| 700 | 1 | _ | |a Carracedo, Angel |b 25 |
| 700 | 1 | _ | |a Castelao, Jose E |b 26 |
| 700 | 1 | _ | |a Chanock, Stephen J |b 27 |
| 700 | 1 | _ | |a Chenevix-Trench, Georgia |b 28 |
| 700 | 1 | _ | |a Consortium, CTS |b 29 |e Collaboration Author |
| 700 | 1 | _ | |a Cordina-Duverger, Emilie |b 30 |
| 700 | 1 | _ | |a Couch, Fergus J |b 31 |
| 700 | 1 | _ | |a Cox, Angela |b 32 |
| 700 | 1 | _ | |a Cross, Simon S |b 33 |
| 700 | 1 | _ | |a Czene, Kamila |b 34 |
| 700 | 1 | _ | |a Dossus, Laure |b 35 |
| 700 | 1 | _ | |a Dugué, Pierre-Antoine |b 36 |
| 700 | 1 | _ | |a Eliassen, A Heather |b 37 |
| 700 | 1 | _ | |a Eriksson, Mikael |b 38 |
| 700 | 1 | _ | |a Evans, D Gareth |b 39 |
| 700 | 1 | _ | |a Fasching, Peter A |b 40 |
| 700 | 1 | _ | |a Figueroa, Jonine D |b 41 |
| 700 | 1 | _ | |a Fletcher, Olivia |b 42 |
| 700 | 1 | _ | |a Flyger, Henrik |b 43 |
| 700 | 1 | _ | |a Gabrielson, Marike |b 44 |
| 700 | 1 | _ | |a Gago-Dominguez, Manuela |b 45 |
| 700 | 1 | _ | |a Giles, Graham G |b 46 |
| 700 | 1 | _ | |a González-Neira, Anna |b 47 |
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| 700 | 1 | _ | |a Hunter, David J |b 62 |
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| 700 | 1 | _ | |a Isaksson, Karolin |b 66 |
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| 700 | 1 | _ | |a Lambrechts, Diether |b 77 |
| 700 | 1 | _ | |a Larson, Nicole L |b 78 |
| 700 | 1 | _ | |a Larsson, Susanna |b 79 |
| 700 | 1 | _ | |a Le Marchand, Loic |b 80 |
| 700 | 1 | _ | |a Lejbkowicz, Flavio |b 81 |
| 700 | 1 | _ | |a Li, Shuai |b 82 |
| 700 | 1 | _ | |a Linet, Martha |b 83 |
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| 773 | _ | _ | |a 10.1186/s13058-023-01691-8 |g Vol. 25, no. 1, p. 93 |0 PERI:(DE-600)2041618-0 |n 1 |p 93 |t Breast cancer research |v 25 |y 2023 |x 1465-5411 |
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