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000278395 041__ $$aEnglish
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000278395 1001_ $$00000-0001-5591-2187$$aHeger, Lukas$$b0
000278395 245__ $$aXCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors.
000278395 260__ $$aWashington, DC$$bNational Acad. of Sciences$$c2023
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000278395 520__ $$aDendritic cells (DCs) are major regulators of innate and adaptive immune responses. DCs can be classified into plasmacytoid DCs and conventional DCs (cDCs) type 1 and 2. Murine and human cDC1 share the mRNA expression of XCR1. Murine studies indicated a specific role of the XCR1-XCL1 axis in the induction of immune responses. Here, we describe that human cDC1 can be distinguished into XCR1- and XCR1+ cDC1 in lymphoid as well as nonlymphoid tissues. Steady-state XCR1+ cDC1 display a preactivated phenotype compared to XCR1- cDC1. Upon stimulation, XCR1+ cDC1, but not XCR1- cDC1, secreted high levels of inflammatory cytokines as well as chemokines. This was associated with enhanced activation of NK cells mediated by XCR1+ cDC1. Moreover, XCR1+ cDC1 excelled in inhibiting replication of Influenza A virus. Further, under DC differentiation conditions, XCR1- cDC1 developed into XCR1+ cDC1. After acquisition of XCR1 expression, XCR1- cDC1 secreted comparable level of inflammatory cytokines. Thus, XCR1 is a marker of terminally differentiated cDC1 that licenses the antiviral effector functions of human cDC1, while XCR1- cDC1 seem to represent a late immediate precursor of cDC1.
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000278395 650_7 $$2Other$$aDC differentiation
000278395 650_7 $$2Other$$aIL-12
000278395 650_7 $$2Other$$aXCR1
000278395 650_7 $$2Other$$aantiviral immunity
000278395 650_7 $$2Other$$acDC1
000278395 7001_ $$aHatscher, Lukas$$b1
000278395 7001_ $$aLiang, Chunguang$$b2
000278395 7001_ $$aLehmann, Christian H K$$b3
000278395 7001_ $$00000-0003-3834-6114$$aAmon, Lukas$$b4
000278395 7001_ $$aLühr, Jennifer J$$b5
000278395 7001_ $$00009-0000-6453-5969$$aKaszubowski, Tomasz$$b6
000278395 7001_ $$00009-0000-3496-7509$$aNzirorera, Rayk$$b7
000278395 7001_ $$aSchaft, Niels$$b8
000278395 7001_ $$00000-0002-3478-0741$$aDörrie, Jan$$b9
000278395 7001_ $$aIrrgang, Pascal$$b10
000278395 7001_ $$aTenbusch, Matthias$$b11
000278395 7001_ $$aKunz, Meik$$b12
000278395 7001_ $$00000-0002-6239-3749$$aSocher, Eileen$$b13
000278395 7001_ $$0P:(DE-He78)d3dbba28fe1239effd15962787cbc363$$aAutenrieth, Stella E$$b14$$udkfz
000278395 7001_ $$00000-0002-5242-2630$$aPurbojo, Ariawan$$b15
000278395 7001_ $$aSirbu, Horia$$b16
000278395 7001_ $$aHartmann, Arndt$$b17
000278395 7001_ $$00000-0003-2220-6790$$aAlexiou, Christoph$$b18
000278395 7001_ $$00000-0002-3575-6647$$aCesnjevar, Robert$$b19
000278395 7001_ $$00000-0001-9358-134X$$aDudziak, Diana$$b20
000278395 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.2300343120$$gVol. 120, no. 33, p. e2300343120$$n33$$pe2300343120$$tProceedings of the National Academy of Sciences of the United States of America$$v120$$x0027-8424$$y2023
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