Journal Article

DKFZ-2023-01629

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors.

Heger, L. ; Hatscher, L. ; Liang, C. ; Lehmann, C. H. K. ; Amon, L. ; Lühr, J. J. ; Kaszubowski, T. ; Nzirorera, R. ; Schaft, N. ; Dörrie, J. ; Irrgang, P. ; Tenbusch, M. ; Kunz, M. ; Socher, E. ; Autenrieth, S. E.DKFZ* ; Purbojo, A. ; Sirbu, H. ; Hartmann, A. ; Alexiou, C. ; Cesnjevar, R. ; Dudziak, D.

2023
National Acad. of Sciences Washington, DC

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Please use a persistent id in citations: doi:10.1073/pnas.2300343120

Abstract: Dendritic cells (DCs) are major regulators of innate and adaptive immune responses. DCs can be classified into plasmacytoid DCs and conventional DCs (cDCs) type 1 and 2. Murine and human cDC1 share the mRNA expression of XCR1. Murine studies indicated a specific role of the XCR1-XCL1 axis in the induction of immune responses. Here, we describe that human cDC1 can be distinguished into XCR1- and XCR1+ cDC1 in lymphoid as well as nonlymphoid tissues. Steady-state XCR1+ cDC1 display a preactivated phenotype compared to XCR1- cDC1. Upon stimulation, XCR1+ cDC1, but not XCR1- cDC1, secreted high levels of inflammatory cytokines as well as chemokines. This was associated with enhanced activation of NK cells mediated by XCR1+ cDC1. Moreover, XCR1+ cDC1 excelled in inhibiting replication of Influenza A virus. Further, under DC differentiation conditions, XCR1- cDC1 developed into XCR1+ cDC1. After acquisition of XCR1 expression, XCR1- cDC1 secreted comparable level of inflammatory cytokines. Thus, XCR1 is a marker of terminally differentiated cDC1 that licenses the antiviral effector functions of human cDC1, while XCR1- cDC1 seem to represent a late immediate precursor of cDC1.

Keyword(s): DC differentiation ; IL-12 ; XCR1 ; antiviral immunity ; cDC1

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Contributing Institute(s):

1. Dentritische Zellen bei Infektionen und Krebs (F171)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; National-Konsortium ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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