000278731 001__ 278731
000278731 005__ 20240229155038.0
000278731 0247_ $$2doi$$a10.1002/path.6165
000278731 0247_ $$2pmid$$apmid:37608771
000278731 0247_ $$2ISSN$$a0368-3494
000278731 0247_ $$2ISSN$$a0022-3417
000278731 0247_ $$2ISSN$$a1096-9896
000278731 0247_ $$2ISSN$$a1555-2039
000278731 0247_ $$2altmetric$$aaltmetric:153260546
000278731 037__ $$aDKFZ-2023-01702
000278731 041__ $$aEnglish
000278731 082__ $$a610
000278731 1001_ $$00000-0001-9264-4628$$aPage, David B$$b0
000278731 245__ $$aSpatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.
000278731 260__ $$aBognor Regis [u.a.]$$bWiley$$c2023
000278731 3367_ $$2DRIVER$$aarticle
000278731 3367_ $$2DataCite$$aOutput Types/Journal article
000278731 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1693400333_15637$$xReview Article
000278731 3367_ $$2BibTeX$$aARTICLE
000278731 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000278731 3367_ $$00$$2EndNote$$aJournal Article
000278731 500__ $$a2023 Aug;260(5):514-532
000278731 520__ $$aModern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland.
000278731 536__ $$0G:(DE-HGF)POF4-314$$a314 - Immunologie und Krebs (POF4-314)$$cPOF4-314$$fPOF IV$$x0
000278731 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000278731 650_7 $$2Other$$aImmunoscore
000278731 650_7 $$2Other$$aTIL
000278731 650_7 $$2Other$$amultispectral immunofluorescence
000278731 650_7 $$2Other$$asTIL score
000278731 650_7 $$2Other$$aspatial heterogeneity
000278731 650_7 $$2Other$$aspatial statistics
000278731 650_7 $$2Other$$atumor infiltrating lymphocytes
000278731 7001_ $$aBroeckx, Glenn$$b1
000278731 7001_ $$00000-0002-5389-7275$$aJahangir, Chowdhury Arif$$b2
000278731 7001_ $$aVerbandt, Sara$$b3
000278731 7001_ $$00000-0002-1577-8718$$aGupta, Rajarsi R$$b4
000278731 7001_ $$aThagaard, Jeppe$$b5
000278731 7001_ $$aKhiroya, Reena$$b6
000278731 7001_ $$aKos, Zuzana$$b7
000278731 7001_ $$aAbduljabbar, Khalid$$b8
000278731 7001_ $$aAcosta Haab, Gabriela$$b9
000278731 7001_ $$aAcs, Balazs$$b10
000278731 7001_ $$aAlmeida, Jonas S$$b11
000278731 7001_ $$aAlvarado-Cabrero, Isabel$$b12
000278731 7001_ $$aAzmoudeh-Ardalan, Farid$$b13
000278731 7001_ $$aBadve, Sunil$$b14
000278731 7001_ $$aBaharun, Nurkhairul Bariyah$$b15
000278731 7001_ $$aBellolio, Enrique R$$b16
000278731 7001_ $$aBheemaraju, Vydehi$$b17
000278731 7001_ $$aBlenman, Kim Rm$$b18
000278731 7001_ $$aBotinelly Mendonça Fujimoto, Luciana$$b19
000278731 7001_ $$aBurgues, Octavio$$b20
000278731 7001_ $$aCheang, Maggie Chon U$$b21
000278731 7001_ $$aCiompi, Francesco$$b22
000278731 7001_ $$aCooper, Lee Ad$$b23
000278731 7001_ $$aCoosemans, An$$b24
000278731 7001_ $$aCorredor, Germán$$b25
000278731 7001_ $$00000-0003-0188-3709$$aDantas Portela, Flavio Luis$$b26
000278731 7001_ $$aDeman, Frederik$$b27
000278731 7001_ $$aDemaria, Sandra$$b28
000278731 7001_ $$aDudgeon, Sarah N$$b29
000278731 7001_ $$00000-0002-3100-7606$$aElghazawy, Mahmoud$$b30
000278731 7001_ $$aEly, Scott$$b31
000278731 7001_ $$aFernandez-Martín, Claudio$$b32
000278731 7001_ $$aFineberg, Susan$$b33
000278731 7001_ $$aFox, Stephen B$$b34
000278731 7001_ $$aGallagher, William M$$b35
000278731 7001_ $$aGiltnane, Jennifer M$$b36
000278731 7001_ $$aGnjatic, Sacha$$b37
000278731 7001_ $$00000-0002-6292-6963$$aGonzalez-Ericsson, Paula I$$b38
000278731 7001_ $$00000-0003-3434-201X$$aGrigoriadis, Anita$$b39
000278731 7001_ $$0P:(DE-He78)0a4053be7ffd6aa9bef69de28753a601$$aHalama, Niels$$b40$$udkfz
000278731 7001_ $$aHanna, Matthew G$$b41
000278731 7001_ $$aHarbhajanka, Aparna$$b42
000278731 7001_ $$00000-0001-9906-7552$$aHardas, Alexandros$$b43
000278731 7001_ $$00000-0001-7714-2734$$aHart, Steven N$$b44
000278731 7001_ $$00000-0002-6500-8527$$aHartman, Johan$$b45
000278731 7001_ $$aHewitt, Stephen$$b46
000278731 7001_ $$aHida, Akira I$$b47
000278731 7001_ $$aHorlings, Hugo M$$b48
000278731 7001_ $$aHusain, Zaheed$$b49
000278731 7001_ $$aHytopoulos, Evangelos$$b50
000278731 7001_ $$aIrshad, Sheeba$$b51
000278731 7001_ $$aJanssen, Emiel Am$$b52
000278731 7001_ $$aKahila, Mohamed$$b53
000278731 7001_ $$00000-0003-3095-8976$$aKataoka, Tatsuki R$$b54
000278731 7001_ $$aKawaguchi, Kosuke$$b55
000278731 7001_ $$aKharidehal, Durga$$b56
000278731 7001_ $$aKhramtsov, Andrey I$$b57
000278731 7001_ $$aKiraz, Umay$$b58
000278731 7001_ $$aKirtani, Pawan$$b59
000278731 7001_ $$aKodach, Liudmila L$$b60
000278731 7001_ $$aKorski, Konstanty$$b61
000278731 7001_ $$aKovács, Anikó$$b62
000278731 7001_ $$aLaenkholm, Anne-Vibeke$$b63
000278731 7001_ $$aLang-Schwarz, Corinna$$b64
000278731 7001_ $$aLarsimont, Denis$$b65
000278731 7001_ $$aLennerz, Jochen K$$b66
000278731 7001_ $$aLerousseau, Marvin$$b67
000278731 7001_ $$aLi, Xiaoxian$$b68
000278731 7001_ $$aLy, Amy$$b69
000278731 7001_ $$aMadabhushi, Anant$$b70
000278731 7001_ $$aMaley, Sai K$$b71
000278731 7001_ $$aManur Narasimhamurthy, Vidya$$b72
000278731 7001_ $$aMarks, Douglas K$$b73
000278731 7001_ $$aMcDonald, Elizabeth S$$b74
000278731 7001_ $$aMehrotra, Ravi$$b75
000278731 7001_ $$aMichiels, Stefan$$b76
000278731 7001_ $$aMinhas, Fayyaz Ul Amir Afsar$$b77
000278731 7001_ $$aMittal, Shachi$$b78
000278731 7001_ $$aMoore, David A$$b79
000278731 7001_ $$aMushtaq, Shamim$$b80
000278731 7001_ $$aNighat, Hussain$$b81
000278731 7001_ $$aPapathomas, Thomas$$b82
000278731 7001_ $$aPenault-Llorca, Frederique$$b83
000278731 7001_ $$aPerera, Rashindrie D$$b84
000278731 7001_ $$aPinard, Christopher J$$b85
000278731 7001_ $$aPinto-Cardenas, Juan Carlos$$b86
000278731 7001_ $$aPruneri, Giancarlo$$b87
000278731 7001_ $$aPusztai, Lajos$$b88
000278731 7001_ $$aRahman, Arman$$b89
000278731 7001_ $$aRajpoot, Nasir Mahmood$$b90
000278731 7001_ $$aRapoport, Bernardo Leon$$b91
000278731 7001_ $$00000-0002-1251-950X$$aRau, Tilman T$$b92
000278731 7001_ $$00000-0003-2969-3173$$aReis-Filho, Jorge S$$b93
000278731 7001_ $$aRibeiro, Joana M$$b94
000278731 7001_ $$00000-0001-5820-4397$$aRimm, David$$b95
000278731 7001_ $$aSalomon, Anne-Vincent$$b96
000278731 7001_ $$aSalto-Tellez, Manuel$$b97
000278731 7001_ $$aSaltz, Joel$$b98
000278731 7001_ $$aSayed, Shahin$$b99
000278731 7001_ $$aSiziopikou, Kalliopi P$$b100
000278731 7001_ $$aSotiriou, Christos$$b101
000278731 7001_ $$aStenzinger, Albrecht$$b102
000278731 7001_ $$aSughayer, Maher A$$b103
000278731 7001_ $$aSur, Daniel$$b104
000278731 7001_ $$aSymmans, Fraser$$b105
000278731 7001_ $$aTanaka, Sunao$$b106
000278731 7001_ $$aTaxter, Timothy$$b107
000278731 7001_ $$aTejpar, Sabine$$b108
000278731 7001_ $$aTeuwen, Jonas$$b109
000278731 7001_ $$aThompson, E Aubrey$$b110
000278731 7001_ $$aTramm, Trine$$b111
000278731 7001_ $$aTran, William T$$b112
000278731 7001_ $$avan der Laak, Jeroen$$b113
000278731 7001_ $$avan Diest, Paul J$$b114
000278731 7001_ $$00009-0006-7638-6431$$aVerghese, Gregory E$$b115
000278731 7001_ $$aViale, Giuseppe$$b116
000278731 7001_ $$aVieth, Michael$$b117
000278731 7001_ $$00000-0002-1251-1559$$aWahab, Noorul$$b118
000278731 7001_ $$aWalter, Thomas$$b119
000278731 7001_ $$aWaumans, Yannick$$b120
000278731 7001_ $$aWen, Hannah Y$$b121
000278731 7001_ $$aYang, Wentao$$b122
000278731 7001_ $$aYuan, Yinyin$$b123
000278731 7001_ $$aAdams, Sylvia$$b124
000278731 7001_ $$aBartlett, John Mark Seaverns$$b125
000278731 7001_ $$aLoibl, Sibylle$$b126
000278731 7001_ $$aDenkert, Carsten$$b127
000278731 7001_ $$aSavas, Peter$$b128
000278731 7001_ $$aLoi, Sherene$$b129
000278731 7001_ $$aSalgado, Roberto$$b130
000278731 7001_ $$aSpecht Stovgaard, Elisabeth$$b131
000278731 7001_ $$aAkturk, Guray$$b132
000278731 7001_ $$aBouchmaa, Najat$$b133
000278731 773__ $$0PERI:(DE-600)1475280-3$$a10.1002/path.6165$$gp. path.6165$$n5$$p514-532$$tThe journal of pathology$$v260$$x0368-3494$$y2023
000278731 909CO $$ooai:inrepo02.dkfz.de:278731$$pVDB
000278731 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0a4053be7ffd6aa9bef69de28753a601$$aDeutsches Krebsforschungszentrum$$b40$$kDKFZ
000278731 9131_ $$0G:(DE-HGF)POF4-314$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImmunologie und Krebs$$x0
000278731 9141_ $$y2023
000278731 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2022-11-22$$wger
000278731 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2022-11-22
000278731 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-22
000278731 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-22
000278731 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-10-21$$wger
000278731 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-21
000278731 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-21
000278731 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-21
000278731 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-21
000278731 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-21
000278731 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-21
000278731 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-10-21
000278731 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ PATHOL : 2022$$d2023-10-21
000278731 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bJ PATHOL : 2022$$d2023-10-21
000278731 9201_ $$0I:(DE-He78)D240-20160331$$kD240$$lTranslationale Immuntherapie$$x0
000278731 980__ $$ajournal
000278731 980__ $$aVDB
000278731 980__ $$aI:(DE-He78)D240-20160331
000278731 980__ $$aUNRESTRICTED