Journal Article (Review Article)

DKFZ-2023-01702

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.

Page, D. B. ; Broeckx, G. ; Jahangir, C. A. ; Verbandt, S. ; Gupta, R. R. ; Thagaard, J. ; Khiroya, R. ; Kos, Z. ; Abduljabbar, K. ; Acosta Haab, G. ; Acs, B. ; Almeida, J. S. ; Alvarado-Cabrero, I. ; Azmoudeh-Ardalan, F. ; Badve, S. ; Baharun, N. B. ; Bellolio, E. R. ; Bheemaraju, V. ; Blenman, K. R. ; Botinelly Mendonça Fujimoto, L. ; Burgues, O. ; Cheang, M. C. U. ; Ciompi, F. ; Cooper, L. A. ; Coosemans, A. ; Corredor, G. ; Dantas Portela, F. L. ; Deman, F. ; Demaria, S. ; Dudgeon, S. N. ; Elghazawy, M. ; Ely, S. ; Fernandez-Martín, C. ; Fineberg, S. ; Fox, S. B. ; Gallagher, W. M. ; Giltnane, J. M. ; Gnjatic, S. ; Gonzalez-Ericsson, P. I. ; Grigoriadis, A. ; Halama, N.DKFZ* ; Hanna, M. G. ; Harbhajanka, A. ; Hardas, A. ; Hart, S. N. ; Hartman, J. ; Hewitt, S. ; Hida, A. I. ; Horlings, H. M. ; Husain, Z. ; Hytopoulos, E. ; Irshad, S. ; Janssen, E. A. ; Kahila, M. ; Kataoka, T. R. ; Kawaguchi, K. ; Kharidehal, D. ; Khramtsov, A. I. ; Kiraz, U. ; Kirtani, P. ; Kodach, L. L. ; Korski, K. ; Kovács, A. ; Laenkholm, A.-V. ; Lang-Schwarz, C. ; Larsimont, D. ; Lennerz, J. K. ; Lerousseau, M. ; Li, X. ; Ly, A. ; Madabhushi, A. ; Maley, S. K. ; Manur Narasimhamurthy, V. ; Marks, D. K. ; McDonald, E. S. ; Mehrotra, R. ; Michiels, S. ; Minhas, F. U. A. A. ; Mittal, S. ; Moore, D. A. ; Mushtaq, S. ; Nighat, H. ; Papathomas, T. ; Penault-Llorca, F. ; Perera, R. D. ; Pinard, C. J. ; Pinto-Cardenas, J. C. ; Pruneri, G. ; Pusztai, L. ; Rahman, A. ; Rajpoot, N. M. ; Rapoport, B. L. ; Rau, T. T. ; Reis-Filho, J. S. ; Ribeiro, J. M. ; Rimm, D. ; Salomon, A.-V. ; Salto-Tellez, M. ; Saltz, J. ; Sayed, S. ; Siziopikou, K. P. ; Sotiriou, C. ; Stenzinger, A. ; Sughayer, M. A. ; Sur, D. ; Symmans, F. ; Tanaka, S. ; Taxter, T. ; Tejpar, S. ; Teuwen, J. ; Thompson, E. A. ; Tramm, T. ; Tran, W. T. ; van der Laak, J. ; van Diest, P. J. ; Verghese, G. E. ; Viale, G. ; Vieth, M. ; Wahab, N. ; Walter, T. ; Waumans, Y. ; Wen, H. Y. ; Yang, W. ; Yuan, Y. ; Adams, S. ; Bartlett, J. M. S. ; Loibl, S. ; Denkert, C. ; Savas, P. ; Loi, S. ; Salgado, R. ; Specht Stovgaard, E. ; Akturk, G. ; Bouchmaa, N.

2023
Wiley Bognor Regis [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/path.6165

Abstract: Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland.

Keyword(s): Immunoscore ; TIL ; multispectral immunofluorescence ; sTIL score ; spatial heterogeneity ; spatial statistics ; tumor infiltrating lymphocytes

Note: 2023 Aug;260(5):514-532

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Contributing Institute(s):

1. Translationale Immuntherapie (D240)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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