guest ::
| Home > Publications database > New insights into RAS in head and neck cancer. |
| Home > Publications database > New insights into RAS in head and neck cancer. |
| Journal Article (Review Article) | DKFZ-2023-01715 |
; ; ; ; ; ; ;
2023
Elsevier
Amsterdam
This record in other databases: 
Please use a persistent id in citations: doi:10.1016/j.bbcan.2023.188963
Abstract: RAS genes are known to be dysregulated in cancer for several decades, and substantial effort has been dedicated to develop agents that reduce RAS expression or block RAS activation. The recent introduction of RAS inhibitors for cancer patients highlights the importance of comprehending RAS alterations in head and neck cancer (HNC). In this regard, we examine the published findings on RAS alterations and pathway activations in HNC, and summarize their role in HNC initiation, progression, and metastasis. Specifically, we focus on the intrinsic role of mutated-RAS on tumor cell signaling and its extrinsic role in determining tumor-microenvironment (TME) heterogeneity, including promoting angiogenesis and enhancing immune escape. Lastly, we summarize the intrinsic and extrinsic role of RAS alterations on therapy resistance to outline the potential of targeting RAS using a single agent or in combination with other therapeutic agents for HNC patients with RAS-activated tumors.
Keyword(s): Head and neck cancer ; Metastasis ; Pre-clinical and clinical targeting ; Progression ; RAS activation ; Therapy resistance
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; Nationallizenz
; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection
|
The record appears in these collections: |