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000282346 0247_ $$2doi$$a10.1056/NEJMoa2206916
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000282346 041__ $$aEnglish
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000282346 1001_ $$aConsortium, Global Cardiovascular Risk$$b0$$eCollaboration Author
000282346 245__ $$aGlobal Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.
000282346 260__ $$aWaltham, Mass.$$bMMS$$c2023
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000282346 500__ $$a2023 Oct 5;389(14):1273-1285
000282346 520__ $$aFive modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).
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000282346 7001_ $$aMagnussen, Christina$$b1
000282346 7001_ $$aOjeda, Francisco M$$b2
000282346 7001_ $$aLeong, Darryl P$$b3
000282346 7001_ $$aAlegre-Diaz, Jesus$$b4
000282346 7001_ $$aAmouyel, Philippe$$b5
000282346 7001_ $$aAviles-Santa, Larissa$$b6
000282346 7001_ $$aDe Bacquer, Dirk$$b7
000282346 7001_ $$aBallantyne, Christie M$$b8
000282346 7001_ $$00000-0002-6834-1376$$aBernabé-Ortiz, Antonio$$b9
000282346 7001_ $$aBobak, Martin$$b10
000282346 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b11$$udkfz
000282346 7001_ $$aCarrillo-Larco, Rodrigo M$$b12
000282346 7001_ $$ade Lemos, James$$b13
000282346 7001_ $$aDobson, Annette$$b14
000282346 7001_ $$aDörr, Marcus$$b15
000282346 7001_ $$aDonfrancesco, Chiara$$b16
000282346 7001_ $$aDrygas, Wojciech$$b17
000282346 7001_ $$aDullaart, Robin P$$b18
000282346 7001_ $$aEngström, Gunnar$$b19
000282346 7001_ $$aFerrario, Marco M$$b20
000282346 7001_ $$aFerrières, Jean$$b21
000282346 7001_ $$ade Gaetano, Giovanni$$b22
000282346 7001_ $$aGoldbourt, Uri$$b23
000282346 7001_ $$aGonzalez, Clicerio$$b24
000282346 7001_ $$aGrassi, Guido$$b25
000282346 7001_ $$aHodge, Allison M$$b26
000282346 7001_ $$aHveem, Kristian$$b27
000282346 7001_ $$aIacoviello, Licia$$b28
000282346 7001_ $$aIkram, M Kamran$$b29
000282346 7001_ $$aIrazola, Vilma$$b30
000282346 7001_ $$aJobe, Modou$$b31
000282346 7001_ $$aJousilahti, Pekka$$b32
000282346 7001_ $$aKaleebu, Pontiano$$b33
000282346 7001_ $$aKavousi, Maryam$$b34
000282346 7001_ $$aKee, Frank$$b35
000282346 7001_ $$00000-0003-4956-1039$$aKhalili, Davood$$b36
000282346 7001_ $$aKoenig, Wolfgang$$b37
000282346 7001_ $$aKontsevaya, Anna$$b38
000282346 7001_ $$aKuulasmaa, Kari$$b39
000282346 7001_ $$aLackner, Karl J$$b40
000282346 7001_ $$aLeistner, David M$$b41
000282346 7001_ $$aLind, Lars$$b42
000282346 7001_ $$aLinneberg, Allan$$b43
000282346 7001_ $$aLorenz, Thiess$$b44
000282346 7001_ $$aNakrem Lyngbakken, Magnus$$b45
000282346 7001_ $$aMalekzadeh, Reza$$b46
000282346 7001_ $$aMalyutina, Sofia$$b47
000282346 7001_ $$00000-0001-8887-6100$$aMathiesen, Ellisiv B$$b48
000282346 7001_ $$aMelander, Olle$$b49
000282346 7001_ $$aMetspalu, Andres$$b50
000282346 7001_ $$00000-0002-4738-5468$$aMiranda, J Jaime$$b51
000282346 7001_ $$aMoitry, Marie$$b52
000282346 7001_ $$aMugisha, Joseph$$b53
000282346 7001_ $$aNalini, Mahdi$$b54
000282346 7001_ $$aNambi, Vijay$$b55
000282346 7001_ $$aNinomiya, Toshiharu$$b56
000282346 7001_ $$aOppermann, Karen$$b57
000282346 7001_ $$ad'Orsi, Eleonora$$b58
000282346 7001_ $$aPająk, Andrzej$$b59
000282346 7001_ $$aPalmieri, Luigi$$b60
000282346 7001_ $$aPanagiotakos, Demosthenes$$b61
000282346 7001_ $$aPerianayagam, Arokiasamy$$b62
000282346 7001_ $$aPeters, Annette$$b63
000282346 7001_ $$aPoustchi, Hossein$$b64
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000282346 7001_ $$aSakata, Satoko$$b70
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000282346 7001_ $$aSepanlou, Sadaf G$$b73
000282346 7001_ $$aSharma, Sanjib Kumar$$b74
000282346 7001_ $$aShaw, Jonathan E$$b75
000282346 7001_ $$aSimons, Leon A$$b76
000282346 7001_ $$00000-0001-9225-1306$$aSöderberg, Stefan$$b77
000282346 7001_ $$aTamosiunas, Abdonas$$b78
000282346 7001_ $$aThorand, Barbara$$b79
000282346 7001_ $$aTunstall-Pedoe, Hugh$$b80
000282346 7001_ $$aTwerenbold, Raphael$$b81
000282346 7001_ $$aVanuzzo, Diego$$b82
000282346 7001_ $$aVeronesi, Giovanni$$b83
000282346 7001_ $$aWaibel, Julia$$b84
000282346 7001_ $$aWannamethee, S Goya$$b85
000282346 7001_ $$aWatanabe, Masafumi$$b86
000282346 7001_ $$aWild, Philipp S$$b87
000282346 7001_ $$aYao, Yao$$b88
000282346 7001_ $$aZeng, Yi$$b89
000282346 7001_ $$00000-0002-8386-5397$$aZiegler, Andreas$$b90
000282346 7001_ $$aBlankenberg, Stefan$$b91
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