Journal Article

DKFZ-2023-01730

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.

Consortium, G. C. R. (Collaboration Author) ; Magnussen, C. ; Ojeda, F. M. ; Leong, D. P. ; Alegre-Diaz, J. ; Amouyel, P. ; Aviles-Santa, L. ; De Bacquer, D. ; Ballantyne, C. M. ; Bernabé-Ortiz, A. ; Bobak, M. ; Brenner, H.DKFZ* ; Carrillo-Larco, R. M. ; de Lemos, J. ; Dobson, A. ; Dörr, M. ; Donfrancesco, C. ; Drygas, W. ; Dullaart, R. P. ; Engström, G. ; Ferrario, M. M. ; Ferrières, J. ; de Gaetano, G. ; Goldbourt, U. ; Gonzalez, C. ; Grassi, G. ; Hodge, A. M. ; Hveem, K. ; Iacoviello, L. ; Ikram, M. K. ; Irazola, V. ; Jobe, M. ; Jousilahti, P. ; Kaleebu, P. ; Kavousi, M. ; Kee, F. ; Khalili, D. ; Koenig, W. ; Kontsevaya, A. ; Kuulasmaa, K. ; Lackner, K. J. ; Leistner, D. M. ; Lind, L. ; Linneberg, A. ; Lorenz, T. ; Nakrem Lyngbakken, M. ; Malekzadeh, R. ; Malyutina, S. ; Mathiesen, E. B. ; Melander, O. ; Metspalu, A. ; Miranda, J. J. ; Moitry, M. ; Mugisha, J. ; Nalini, M. ; Nambi, V. ; Ninomiya, T. ; Oppermann, K. ; d'Orsi, E. ; Pająk, A. ; Palmieri, L. ; Panagiotakos, D. ; Perianayagam, A. ; Peters, A. ; Poustchi, H. ; Prentice, A. M. ; Prescott, E. ; Risérus, U. ; Salomaa, V. ; Sans, S. ; Sakata, S. ; Schöttker, B.DKFZ* ; Schutte, A. E. ; Sepanlou, S. G. ; Sharma, S. K. ; Shaw, J. E. ; Simons, L. A. ; Söderberg, S. ; Tamosiunas, A. ; Thorand, B. ; Tunstall-Pedoe, H. ; Twerenbold, R. ; Vanuzzo, D. ; Veronesi, G. ; Waibel, J. ; Wannamethee, S. G. ; Watanabe, M. ; Wild, P. S. ; Yao, Y. ; Zeng, Y. ; Ziegler, A. ; Blankenberg, S.

2023
MMS Waltham, Mass.

This record in other databases:  

Please use a persistent id in citations: doi:10.1056/NEJMoa2206916

Abstract: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).

Note: 2023 Oct 5;389(14):1273-1285

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 90 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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