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@ARTICLE{Consortium:282346,
      author       = {C. Magnussen and F. M. Ojeda and D. P. Leong and J.
                      Alegre-Diaz and P. Amouyel and L. Aviles-Santa and D. De
                      Bacquer and C. M. Ballantyne and A. Bernabé-Ortiz and M.
                      Bobak and H. Brenner$^*$ and R. M. Carrillo-Larco and J. de
                      Lemos and A. Dobson and M. Dörr and C. Donfrancesco and W.
                      Drygas and R. P. Dullaart and G. Engström and M. M.
                      Ferrario and J. Ferrières and G. de Gaetano and U.
                      Goldbourt and C. Gonzalez and G. Grassi and A. M. Hodge and
                      K. Hveem and L. Iacoviello and M. K. Ikram and V. Irazola
                      and M. Jobe and P. Jousilahti and P. Kaleebu and M. Kavousi
                      and F. Kee and D. Khalili and W. Koenig and A. Kontsevaya
                      and K. Kuulasmaa and K. J. Lackner and D. M. Leistner and L.
                      Lind and A. Linneberg and T. Lorenz and M. Nakrem Lyngbakken
                      and R. Malekzadeh and S. Malyutina and E. B. Mathiesen and
                      O. Melander and A. Metspalu and J. J. Miranda and M. Moitry
                      and J. Mugisha and M. Nalini and V. Nambi and T. Ninomiya
                      and K. Oppermann and E. d'Orsi and A. Pająk and L. Palmieri
                      and D. Panagiotakos and A. Perianayagam and A. Peters and H.
                      Poustchi and A. M. Prentice and E. Prescott and U. Risérus
                      and V. Salomaa and S. Sans and S. Sakata and B.
                      Schöttker$^*$ and A. E. Schutte and S. G. Sepanlou and S.
                      K. Sharma and J. E. Shaw and L. A. Simons and S. Söderberg
                      and A. Tamosiunas and B. Thorand and H. Tunstall-Pedoe and
                      R. Twerenbold and D. Vanuzzo and G. Veronesi and J. Waibel
                      and S. G. Wannamethee and M. Watanabe and P. S. Wild and Y.
                      Yao and Y. Zeng and A. Ziegler and S. Blankenberg},
      collaboration = {G. C. R. Consortium},
      title        = {{G}lobal {E}ffect of {M}odifiable {R}isk {F}actors on
                      {C}ardiovascular {D}isease and {M}ortality.},
      journal      = {The New England journal of medicine},
      volume       = {389},
      number       = {14},
      issn         = {0028-4793},
      address      = {Waltham, Mass.},
      publisher    = {MMS},
      reportid     = {DKFZ-2023-01730},
      pages        = {1273-1285},
      year         = {2023},
      note         = {2023 Oct 5;389(14):1273-1285},
      abstract     = {Five modifiable risk factors are associated with
                      cardiovascular disease and death from any cause. Studies
                      using individual-level data to evaluate the regional and
                      sex-specific prevalence of the risk factors and their effect
                      on these outcomes are lacking.We pooled and harmonized
                      individual-level data from 112 cohort studies conducted in
                      34 countries and 8 geographic regions participating in the
                      Global Cardiovascular Risk Consortium. We examined
                      associations between the risk factors (body-mass index,
                      systolic blood pressure, non-high-density lipoprotein
                      cholesterol, current smoking, and diabetes) and incident
                      cardiovascular disease and death from any cause using Cox
                      regression analyses, stratified according to geographic
                      region, age, and sex. Population-attributable fractions were
                      estimated for the 10-year incidence of cardiovascular
                      disease and 10-year all-cause mortality.Among 1,518,028
                      participants $(54.1\%$ of whom were women) with a median age
                      of 54.4 years, regional variations in the prevalence of the
                      five modifiable risk factors were noted. Incident
                      cardiovascular disease occurred in 80,596 participants
                      during a median follow-up of 7.3 years (maximum, 47.3), and
                      177,369 participants died during a median follow-up of 8.7
                      years (maximum, 47.6). For all five risk factors combined,
                      the aggregate global population-attributable fraction of the
                      10-year incidence of cardiovascular disease was $57.2\%$
                      $(95\%$ confidence interval [CI], 52.4 to 62.1) among women
                      and $52.6\%$ $(95\%$ CI, 49.0 to 56.1) among men, and the
                      corresponding values for 10-year all-cause mortality were
                      $22.2\%$ $(95\%$ CI, 16.8 to 27.5) and $19.1\%$ $(95\%$ CI,
                      14.6 to 23.6).Harmonized individual-level data from a global
                      cohort showed that $57.2\%$ and $52.6\%$ of cases of
                      incident cardiovascular disease among women and men,
                      respectively, and $22.2\%$ and $19.1\%$ of deaths from any
                      cause among women and men, respectively, may be attributable
                      to five modifiable risk factors. (Funded by the German
                      Center for Cardiovascular Research (DZHK);
                      ClinicalTrials.gov number, NCT05466825.).},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37632466},
      doi          = {10.1056/NEJMoa2206916},
      url          = {https://inrepo02.dkfz.de/record/282346},
}