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| 001 | 282346 | ||
| 005 | 20240229155039.0 | ||
| 024 | 7 | _ | |a 10.1056/NEJMoa2206916 |2 doi |
| 024 | 7 | _ | |a pmid:37632466 |2 pmid |
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| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Consortium, Global Cardiovascular Risk |b 0 |e Collaboration Author |
| 245 | _ | _ | |a Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. |
| 260 | _ | _ | |a Waltham, Mass. |c 2023 |b MMS |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1698323875_31145 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2023 Oct 5;389(14):1273-1285 |
| 520 | _ | _ | |a Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.). |
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| 700 | 1 | _ | |a Magnussen, Christina |b 1 |
| 700 | 1 | _ | |a Ojeda, Francisco M |b 2 |
| 700 | 1 | _ | |a Leong, Darryl P |b 3 |
| 700 | 1 | _ | |a Alegre-Diaz, Jesus |b 4 |
| 700 | 1 | _ | |a Amouyel, Philippe |b 5 |
| 700 | 1 | _ | |a Aviles-Santa, Larissa |b 6 |
| 700 | 1 | _ | |a De Bacquer, Dirk |b 7 |
| 700 | 1 | _ | |a Ballantyne, Christie M |b 8 |
| 700 | 1 | _ | |a Bernabé-Ortiz, Antonio |0 0000-0002-6834-1376 |b 9 |
| 700 | 1 | _ | |a Bobak, Martin |b 10 |
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| 700 | 1 | _ | |a Carrillo-Larco, Rodrigo M |b 12 |
| 700 | 1 | _ | |a de Lemos, James |b 13 |
| 700 | 1 | _ | |a Dobson, Annette |b 14 |
| 700 | 1 | _ | |a Dörr, Marcus |b 15 |
| 700 | 1 | _ | |a Donfrancesco, Chiara |b 16 |
| 700 | 1 | _ | |a Drygas, Wojciech |b 17 |
| 700 | 1 | _ | |a Dullaart, Robin P |b 18 |
| 700 | 1 | _ | |a Engström, Gunnar |b 19 |
| 700 | 1 | _ | |a Ferrario, Marco M |b 20 |
| 700 | 1 | _ | |a Ferrières, Jean |b 21 |
| 700 | 1 | _ | |a de Gaetano, Giovanni |b 22 |
| 700 | 1 | _ | |a Goldbourt, Uri |b 23 |
| 700 | 1 | _ | |a Gonzalez, Clicerio |b 24 |
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| 700 | 1 | _ | |a Kaleebu, Pontiano |b 33 |
| 700 | 1 | _ | |a Kavousi, Maryam |b 34 |
| 700 | 1 | _ | |a Kee, Frank |b 35 |
| 700 | 1 | _ | |a Khalili, Davood |0 0000-0003-4956-1039 |b 36 |
| 700 | 1 | _ | |a Koenig, Wolfgang |b 37 |
| 700 | 1 | _ | |a Kontsevaya, Anna |b 38 |
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| 700 | 1 | _ | |a Lackner, Karl J |b 40 |
| 700 | 1 | _ | |a Leistner, David M |b 41 |
| 700 | 1 | _ | |a Lind, Lars |b 42 |
| 700 | 1 | _ | |a Linneberg, Allan |b 43 |
| 700 | 1 | _ | |a Lorenz, Thiess |b 44 |
| 700 | 1 | _ | |a Nakrem Lyngbakken, Magnus |b 45 |
| 700 | 1 | _ | |a Malekzadeh, Reza |b 46 |
| 700 | 1 | _ | |a Malyutina, Sofia |b 47 |
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| 700 | 1 | _ | |a Blankenberg, Stefan |b 91 |
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