TY  - JOUR
AU  - Baltazar, Filipa
AU  - Tessonnier, Thomas
AU  - Haberer, Thomas
AU  - Debus, Jürgen
AU  - Herfarth, Klaus
AU  - Tawk, Bouchra
AU  - Knoll, Maximillian
AU  - Abdollahi, Amir
AU  - Liermann, Jakob
AU  - Mairani, Andrea
TI  - Carbon-ion Radiotherapy (CIRT) as treatment of pancreatic cancer at HIT: initial radiation plan analysis of the prospective phase II PACK-study.
JO  - Radiotherapy and oncology
VL  - 188
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2023-01743
SP  - 109872
PY  - 2023
N1  - #EA:E050#LA:E050# / Volume 188, November 2023, 109872
AB  - To analyze the dose objectives and constraints applied at the prospective phase II PACK-study at Heidelberg ion therapy center (HIT) for different radiobiological models.Treatment plans of 14 patients from the PACK-study were analyzed and recomputed in terms of physical, biological dose and dose-averaged linear energy transfer (LETd). Both LEM-I (local effect model 1) and the adapted NIRS-MKM (microdosimetric kinetic model), were used for relative biological effectiveness (RBE)-weighted dose calculations (DBio - HIT and DBio - NIRS). A new constraint to the gastrointestinal (GI) tract was derived from the National Institute of Radiological Science (NIRS) clinical experience and considered for plan reoptimization (DBio - NIRS-const_48Gy. and DBio - NIRS-const_50.4Gy). The Lyman-Kutcher-Burman (LKB) model of Normal Tissue Complication Probability (NTCP) for GI toxicity endpoints was computed. Furthermore, the computed LETd distribution was evaluated and correlated with Local Control (LC).Only two patients showed a LETd98
KW  - Gastrointestinal toxicity (Other)
KW  - Pancreatic cancer (Other)
KW  - Treatment dose constraints (Other)
KW  - carbon ion radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37634764
DO  - DOI:10.1016/j.radonc.2023.109872
UR  - https://inrepo02.dkfz.de/record/282359
ER  -