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@ARTICLE{Edsj:282367,
      author       = {A. Edsjö and L. Holmquist and B. Geoerger and F. Nowak and
                      G. Gomon and C. Alix-Panabières and C. Ploeger and U.
                      Lassen and C. Le Tourneau and J. Lehtiö and P. A. Ott and
                      A. von Deimling$^*$ and S. Fröhling$^*$ and E. Voest and F.
                      Klauschen$^*$ and R. Dienstmann and A. Alshibany and L. L.
                      Siu and A. Stenzinger},
      title        = {{P}recision cancer medicine: {C}oncepts, current practice,
                      and future developments.},
      journal      = {Journal of internal medicine},
      volume       = {294},
      number       = {4},
      issn         = {0001-6101},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2023-01749},
      pages        = {455-481},
      year         = {2023},
      note         = {2023 Oct;294(4):455-481},
      abstract     = {Precision cancer medicine is a multidisciplinary team
                      effort that requires involvement and commitment of many
                      stakeholders including the society at large. Building on the
                      success of significant advances in precision therapy for
                      oncological patients over the last two decades, future
                      developments will be significantly shaped by improvements in
                      scalable molecular diagnostics in which increasingly complex
                      multilayered datasets require transformation into clinically
                      useful information guiding patient management at fast
                      turnaround times. Adaptive profiling strategies involving
                      tissue- and liquid-based testing that account for the
                      immense plasticity of cancer during the patient's journey
                      and also include early detection approaches are already
                      finding their way into clinical routine and will become
                      paramount. A second major driver is the development of smart
                      clinical trials and trial concepts which, complemented by
                      real-world evidence, rapidly broaden the spectrum of
                      therapeutic options. Tight coordination with regulatory
                      agencies and health technology assessment bodies is crucial
                      in this context. Multicentric networks operating nationally
                      and internationally are key in implementing precision
                      oncology in clinical practice and support developing and
                      improving the ecosystem and framework needed to turn
                      invocation into benefits for patients. The review provides
                      an overview of the diagnostic tools, innovative clinical
                      studies, and collaborative efforts needed to realize
                      precision cancer medicine.},
      subtyp        = {Review Article},
      keywords     = {clinical trials (Other) / molecular diagnostics (Other) /
                      personalized oncology (Other) / precision cancer medicine
                      (Other) / precision medicine networks (Other)},
      cin          = {B300 / B340 / HD01 / BE01 / MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)B340-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)BE01-20160331 /
                      I:(DE-He78)MU01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37641393},
      doi          = {10.1111/joim.13709},
      url          = {https://inrepo02.dkfz.de/record/282367},
}