Journal Article (Review Article)

DKFZ-2023-01749

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Precision cancer medicine: Concepts, current practice, and future developments.

Edsjö, A. ; Holmquist, L. ; Geoerger, B. ; Nowak, F. ; Gomon, G. ; Alix-Panabières, C. ; Ploeger, C. ; Lassen, U. ; Le Tourneau, C. ; Lehtiö, J. ; Ott, P. A. ; von Deimling, A.DKFZ* ; Fröhling, S.DKFZ* ; Voest, E. ; Klauschen, F.DKFZ* ; Dienstmann, R. ; Alshibany, A. ; Siu, L. L. ; Stenzinger, A.

2023
Wiley-Blackwell Oxford [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1111/joim.13709

Abstract: Precision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological patients over the last two decades, future developments will be significantly shaped by improvements in scalable molecular diagnostics in which increasingly complex multilayered datasets require transformation into clinically useful information guiding patient management at fast turnaround times. Adaptive profiling strategies involving tissue- and liquid-based testing that account for the immense plasticity of cancer during the patient's journey and also include early detection approaches are already finding their way into clinical routine and will become paramount. A second major driver is the development of smart clinical trials and trial concepts which, complemented by real-world evidence, rapidly broaden the spectrum of therapeutic options. Tight coordination with regulatory agencies and health technology assessment bodies is crucial in this context. Multicentric networks operating nationally and internationally are key in implementing precision oncology in clinical practice and support developing and improving the ecosystem and framework needed to turn invocation into benefits for patients. The review provides an overview of the diagnostic tools, innovative clinical studies, and collaborative efforts needed to realize precision cancer medicine.

Keyword(s): clinical trials ; molecular diagnostics ; personalized oncology ; precision cancer medicine ; precision medicine networks

Note: 2023 Oct;294(4):455-481

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Contributing Institute(s):

1. KKE Neuropathologie (B300)
2. Translationale Medizinische Onkologie (B340)
3. DKTK HD zentral (HD01)
4. DKTK Koordinierungsstelle Berlin (BE01)
5. DKTK Koordinierungsstelle München (MU01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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