%0 Journal Article
%A Kapitza, Laura
%A Ho, Naphang
%A Kerzel, Thomas
%A Frank, Annika M
%A Thalheimer, Frederic B
%A Jamali, Arezoo
%A Schaser, Thomas
%A Buchholz, Christian J
%A Hartmann, Jessica
%T CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes.
%J Frontiers in immunology
%V 14
%@ 1664-3224
%C Lausanne
%I Frontiers Media
%M DKFZ-2023-01753
%P 1183698
%D 2023
%X Chimeric antigen receptor (CAR)-expressing T cells are a complex and heterogeneous gene therapy product with variable phenotype compositions. A higher proportion of less differentiated CAR T cells is usually associated with improved antitumoral function and persistence. We describe in this study a novel receptor-targeted lentiviral vector (LV) named 62L-LV that preferentially transduces less differentiated T cells marked by the L-selectin receptor CD62L, with transduction rates of up to 70
%K CAR T cells (Other)
%K L-selectin (Other)
%K LV (Other)
%K chimeric antigen receptor (Other)
%K naïve T lymphocytes (Other)
%K receptor-targeted viral vectors (Other)
%K ΔLNGFR (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37646032
%2 pmc:PMC10461316
%R 10.3389/fimmu.2023.1183698
%U https://inrepo02.dkfz.de/record/282426