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@ARTICLE{Zhao:282669,
      author       = {Y. Zhao and A. Ray and K. Broberg and M. Kippler and C. M.
                      Lill and P. Vineis and V. A. Katzke$^*$ and M.
                      Rodriguez-Barranco and M.-D. Chirlaque and M. Guevara and
                      J.-H. Gómez and J. Hansen and S. Panico and L. T. Middleton
                      and G. Masala and V. Pala and A. Vinagre-Aragon and M.
                      Zibetti and R. Vermeulen and S. Peters},
      title        = {{P}rediagnostic {B}lood {M}etal {L}evels and the {R}isk of
                      {P}arkinson's {D}isease: {A} {L}arge {E}uropean
                      {P}rospective {C}ohort.},
      journal      = {Movement disorders},
      volume       = {38},
      number       = {12},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-01815},
      pages        = {2302-2307},
      year         = {2023},
      note         = {2023 Dec;38(12):2302-2307},
      abstract     = {Metals have been postulated as environmental concerns in
                      the etiology of Parkinson's disease (PD), but metal levels
                      are typically measured after diagnosis, which might be
                      subject to reverse causality.The aim of this study was to
                      investigate the association between prediagnostic blood
                      metal levels and PD risk.A case-control study was nested in
                      a prospective European cohort, using erythrocyte samples
                      collected before PD diagnosis.Most assessed metals were not
                      associated with PD risk. Cadmium has a suggestive negative
                      association with PD (odds ratio $[95\%$ confidence interval]
                      for the highest quartile, 0.70 [0.42-1.17]), which
                      diminished among never smokers. Among current smokers only,
                      lead was associated with decreased PD risk (0.06
                      [0.01-0.35]), whereas arsenic showed associations toward an
                      increased PD risk (1.85 [0.45-7.93]).We observe no strong
                      evidence to support a role of metals in the development of
                      PD. In particular, smoking may confound the association with
                      tobacco-derived metals. © 2023 The Authors. Movement
                      Disorders published by Wiley Periodicals LLC on behalf of
                      International Parkinson and Movement Disorder Society.},
      keywords     = {Parkinson's disease (Other) / cohort study (Other) / metals
                      (Other) / prospective exposure assessment (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37675653},
      doi          = {10.1002/mds.29602},
      url          = {https://inrepo02.dkfz.de/record/282669},
}