Journal Article

DKFZ-2023-01815

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort.

Zhao, Y. ; Ray, A. ; Broberg, K. ; Kippler, M. ; Lill, C. M. ; Vineis, P. ; Katzke, V. A.DKFZ* ; Rodriguez-Barranco, M. ; Chirlaque, M.-D. ; Guevara, M. ; Gómez, J.-H. ; Hansen, J. ; Panico, S. ; Middleton, L. T. ; Masala, G. ; Pala, V. ; Vinagre-Aragon, A. ; Zibetti, M. ; Vermeulen, R. ; Peters, S.

2023
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.29602

Abstract: Metals have been postulated as environmental concerns in the etiology of Parkinson's disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality.The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk.A case-control study was nested in a prospective European cohort, using erythrocyte samples collected before PD diagnosis.Most assessed metals were not associated with PD risk. Cadmium has a suggestive negative association with PD (odds ratio [95% confidence interval] for the highest quartile, 0.70 [0.42-1.17]), which diminished among never smokers. Among current smokers only, lead was associated with decreased PD risk (0.06 [0.01-0.35]), whereas arsenic showed associations toward an increased PD risk (1.85 [0.45-7.93]).We observe no strong evidence to support a role of metals in the development of PD. In particular, smoking may confound the association with tobacco-derived metals. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyword(s): Parkinson's disease ; cohort study ; metals ; prospective exposure assessment

Note: 2023 Dec;38(12):2302-2307

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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