TY  - JOUR
AU  - Kolb, Svenja
AU  - Hoffmann, Inga
AU  - Monjé, Nanna
AU  - Dragomir, Mihnea P
AU  - Jank, Paul
AU  - Bischoff, Philip
AU  - Keunecke, Carlotta
AU  - Pohl, Jonathan
AU  - Kunze, Catarina Alisa
AU  - Marchenko, Sofya
AU  - Schmitt, Wolfgang D
AU  - Kulbe, Hagen
AU  - Sers, Christine
AU  - Sehouli, Jalid
AU  - Braicu, Elena Ioana
AU  - Denkert, Carsten
AU  - Darb-Esfahani, Silvia
AU  - Horst, David
AU  - Sinn, Bruno V
AU  - Taube, Eliane T
TI  - LRP1B - a prognostic marker in tubo-ovarian high-grade serous carcinoma.
JO  - Human pathology
VL  - 141
SN  - 0046-8177
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-01933
SP  - 158-168
PY  - 2023
N1  - 2023 Nov;141:158-168
AB  - LDL Receptor Related Protein 1B (LRP1B) is a member of the low-density lipoprotein (LDL) receptor family and has often been discussed as a tumor suppressor gene, as its downregulation is correlated with a poor prognosis in multiple carcinoma entities. Due to the high metastasis rate into the fatty peritoneal cavity and current research findings showing a dysregulation of lipid metabolism in tubo-ovarian high-grade serous carcinoma (HGSC), we questioned the prognostic impact of the LRP1B protein expression.We examined a well characterized large cohort of 571 patients with primary HGSC and analyzed the LRP1B protein expression via immunohistochemical staining (both in tumor and stroma cells separately), performed precise bioimage analysis with QuPath and calculated the prognostic impact using SPSS.Our results demonstrate that LRP1B functions as a significant prognostic marker for overall survival (OS) and progression free survival (PFS) in HGSC on the protein level. High cytoplasmic expression of LRP1B in tumor, in stroma and in combined tumor and stroma cells has a significantly positive association with a mean prolongation of the OS by 42 months (p=0.005), 29 months (p=0.005) and 25 months (p=0.001) respectively. Additionally, the mean PFS was 18 months longer in tumor (p=0.002), 19 months in stroma (p=0.004) and 19 months in both cell types combined (p=0.01). Our results remained significant in multivariate analysis.We envision LRP1B as a potential prognostic tool that could help us understand the functional role of lipid metabolism in advanced HGSC, especially regarding liposomal medications.
KW  - HGSC (Other)
KW  - HGSOC (Other)
KW  - LRP1B (Other)
KW  - prognostic marker (Other)
KW  - tubo-ovarian carcinoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37742945
DO  - DOI:10.1016/j.humpath.2023.09.001
UR  - https://inrepo02.dkfz.de/record/283147
ER  -