Journal Article

DKFZ-2023-01933

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png LRP1B - a prognostic marker in tubo-ovarian high-grade serous carcinoma.

Kolb, S. ; Hoffmann, I. ; Monjé, N. ; Dragomir, M. P.DKFZ* ; Jank, P. ; Bischoff, P. ; Keunecke, C. ; Pohl, J. ; Kunze, C. A. ; Marchenko, S. ; Schmitt, W. D. ; Kulbe, H. ; Sers, C. ; Sehouli, J. ; Braicu, E. I. ; Denkert, C. ; Darb-Esfahani, S. ; Horst, D. ; Sinn, B. V. ; Taube, E. T.

2023
Elsevier New York, NY [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.humpath.2023.09.001

Abstract: LDL Receptor Related Protein 1B (LRP1B) is a member of the low-density lipoprotein (LDL) receptor family and has often been discussed as a tumor suppressor gene, as its downregulation is correlated with a poor prognosis in multiple carcinoma entities. Due to the high metastasis rate into the fatty peritoneal cavity and current research findings showing a dysregulation of lipid metabolism in tubo-ovarian high-grade serous carcinoma (HGSC), we questioned the prognostic impact of the LRP1B protein expression.We examined a well characterized large cohort of 571 patients with primary HGSC and analyzed the LRP1B protein expression via immunohistochemical staining (both in tumor and stroma cells separately), performed precise bioimage analysis with QuPath and calculated the prognostic impact using SPSS.Our results demonstrate that LRP1B functions as a significant prognostic marker for overall survival (OS) and progression free survival (PFS) in HGSC on the protein level. High cytoplasmic expression of LRP1B in tumor, in stroma and in combined tumor and stroma cells has a significantly positive association with a mean prolongation of the OS by 42 months (p=0.005), 29 months (p=0.005) and 25 months (p=0.001) respectively. Additionally, the mean PFS was 18 months longer in tumor (p=0.002), 19 months in stroma (p=0.004) and 19 months in both cell types combined (p=0.01). Our results remained significant in multivariate analysis.We envision LRP1B as a potential prognostic tool that could help us understand the functional role of lipid metabolism in advanced HGSC, especially regarding liposomal medications.

Keyword(s): HGSC ; HGSOC ; LRP1B ; prognostic marker ; tubo-ovarian carcinoma

Note: 2023 Nov;141:158-168

---

Contributing Institute(s):

1. DKTK Koordinierungsstelle Berlin (BE01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---