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@ARTICLE{Kolb:283147,
      author       = {S. Kolb and I. Hoffmann and N. Monjé and M. P.
                      Dragomir$^*$ and P. Jank and P. Bischoff and C. Keunecke and
                      J. Pohl and C. A. Kunze and S. Marchenko and W. D. Schmitt
                      and H. Kulbe and C. Sers and J. Sehouli and E. I. Braicu and
                      C. Denkert and S. Darb-Esfahani and D. Horst and B. V. Sinn
                      and E. T. Taube},
      title        = {{LRP}1{B} - a prognostic marker in tubo-ovarian high-grade
                      serous carcinoma.},
      journal      = {Human pathology},
      volume       = {141},
      issn         = {0046-8177},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-01933},
      pages        = {158-168},
      year         = {2023},
      note         = {2023 Nov;141:158-168},
      abstract     = {LDL Receptor Related Protein 1B (LRP1B) is a member of the
                      low-density lipoprotein (LDL) receptor family and has often
                      been discussed as a tumor suppressor gene, as its
                      downregulation is correlated with a poor prognosis in
                      multiple carcinoma entities. Due to the high metastasis rate
                      into the fatty peritoneal cavity and current research
                      findings showing a dysregulation of lipid metabolism in
                      tubo-ovarian high-grade serous carcinoma (HGSC), we
                      questioned the prognostic impact of the LRP1B protein
                      expression.We examined a well characterized large cohort of
                      571 patients with primary HGSC and analyzed the LRP1B
                      protein expression via immunohistochemical staining (both in
                      tumor and stroma cells separately), performed precise
                      bioimage analysis with QuPath and calculated the prognostic
                      impact using SPSS.Our results demonstrate that LRP1B
                      functions as a significant prognostic marker for overall
                      survival (OS) and progression free survival (PFS) in HGSC on
                      the protein level. High cytoplasmic expression of LRP1B in
                      tumor, in stroma and in combined tumor and stroma cells has
                      a significantly positive association with a mean
                      prolongation of the OS by 42 months (p=0.005), 29 months
                      (p=0.005) and 25 months (p=0.001) respectively.
                      Additionally, the mean PFS was 18 months longer in tumor
                      (p=0.002), 19 months in stroma (p=0.004) and 19 months in
                      both cell types combined (p=0.01). Our results remained
                      significant in multivariate analysis.We envision LRP1B as a
                      potential prognostic tool that could help us understand the
                      functional role of lipid metabolism in advanced HGSC,
                      especially regarding liposomal medications.},
      keywords     = {HGSC (Other) / HGSOC (Other) / LRP1B (Other) / prognostic
                      marker (Other) / tubo-ovarian carcinoma (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37742945},
      doi          = {10.1016/j.humpath.2023.09.001},
      url          = {https://inrepo02.dkfz.de/record/283147},
}