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@ARTICLE{Kolb:283147,
author = {S. Kolb and I. Hoffmann and N. Monjé and M. P.
Dragomir$^*$ and P. Jank and P. Bischoff and C. Keunecke and
J. Pohl and C. A. Kunze and S. Marchenko and W. D. Schmitt
and H. Kulbe and C. Sers and J. Sehouli and E. I. Braicu and
C. Denkert and S. Darb-Esfahani and D. Horst and B. V. Sinn
and E. T. Taube},
title = {{LRP}1{B} - a prognostic marker in tubo-ovarian high-grade
serous carcinoma.},
journal = {Human pathology},
volume = {141},
issn = {0046-8177},
address = {New York, NY [u.a.]},
publisher = {Elsevier},
reportid = {DKFZ-2023-01933},
pages = {158-168},
year = {2023},
note = {2023 Nov;141:158-168},
abstract = {LDL Receptor Related Protein 1B (LRP1B) is a member of the
low-density lipoprotein (LDL) receptor family and has often
been discussed as a tumor suppressor gene, as its
downregulation is correlated with a poor prognosis in
multiple carcinoma entities. Due to the high metastasis rate
into the fatty peritoneal cavity and current research
findings showing a dysregulation of lipid metabolism in
tubo-ovarian high-grade serous carcinoma (HGSC), we
questioned the prognostic impact of the LRP1B protein
expression.We examined a well characterized large cohort of
571 patients with primary HGSC and analyzed the LRP1B
protein expression via immunohistochemical staining (both in
tumor and stroma cells separately), performed precise
bioimage analysis with QuPath and calculated the prognostic
impact using SPSS.Our results demonstrate that LRP1B
functions as a significant prognostic marker for overall
survival (OS) and progression free survival (PFS) in HGSC on
the protein level. High cytoplasmic expression of LRP1B in
tumor, in stroma and in combined tumor and stroma cells has
a significantly positive association with a mean
prolongation of the OS by 42 months (p=0.005), 29 months
(p=0.005) and 25 months (p=0.001) respectively.
Additionally, the mean PFS was 18 months longer in tumor
(p=0.002), 19 months in stroma (p=0.004) and 19 months in
both cell types combined (p=0.01). Our results remained
significant in multivariate analysis.We envision LRP1B as a
potential prognostic tool that could help us understand the
functional role of lipid metabolism in advanced HGSC,
especially regarding liposomal medications.},
keywords = {HGSC (Other) / HGSOC (Other) / LRP1B (Other) / prognostic
marker (Other) / tubo-ovarian carcinoma (Other)},
cin = {BE01},
ddc = {610},
cid = {I:(DE-He78)BE01-20160331},
pnm = {899 - ohne Topic (POF4-899)},
pid = {G:(DE-HGF)POF4-899},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:37742945},
doi = {10.1016/j.humpath.2023.09.001},
url = {https://inrepo02.dkfz.de/record/283147},
}