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@ARTICLE{Kaczmarek:283150,
      author       = {I. Kaczmarek and I. Wower and K. Ettig and C. K. Kuhn and
                      R. Kraft and K. Landgraf and A. Körner and T. Schöneberg
                      and S. Horn$^*$ and D. Thor},
      title        = {{I}dentifying {G} protein-coupled receptors involved in
                      adipose tissue function using the innovative {RNA}-seq
                      database {FATTLAS}},
      journal      = {iScience},
      volume       = {26},
      number       = {10},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-01936},
      pages        = {107841},
      year         = {2023},
      abstract     = {G protein-coupled receptors (GPCRs) modulate the function
                      of adipose tissue (AT) in general and of adipocytes,
                      specifically. Although it is well-established that GPCRs are
                      widely expressed in AT, their repertoire as well as their
                      regulation and function in (patho)physiological conditions
                      (e.g., obesity) is not fullyresolved. Here, we established
                      FATTLAS, an interactive public database, for improved access
                      and analysisof RNA-seq data of mouse and human AT. After
                      extracting the GPCRome of non-obese and obese individuals,
                      highly expressed and differentially regulated GPCRs were
                      identified. Exemplarily, we describe fourreceptors (GPR146,
                      MRGPRF, FZD5, PTGER2) and analyzed their functions in a
                      (pre)adipocyte cell model.Besides all receptors being
                      involved in adipogenesis, MRGPRF is essential for adipocyte
                      viability and regulates cAMP levels, while GPR146 modulates
                      adipocyte lipolysis via constitutive activation of Gi
                      proteins.Taken together, by implementing and using FATTLAS
                      we describe four hitherto unrecognized GPCRsassociated with
                      AT function and adipogenesis.},
      cin          = {ED01},
      ddc          = {050},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37766984},
      doi          = {10.1016/j.isci.2023.107841},
      url          = {https://inrepo02.dkfz.de/record/283150},
}