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| Home > Publications database > Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS |
| Home > Publications database > Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS |
| Journal Article | DKFZ-2023-01936 |
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2023
Elsevier
St. Louis
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Please use a persistent id in citations: doi:10.1016/j.isci.2023.107841
Abstract: G protein-coupled receptors (GPCRs) modulate the function of adipose tissue (AT) in general and of adipocytes, specifically. Although it is well-established that GPCRs are widely expressed in AT, their repertoire as well as their regulation and function in (patho)physiological conditions (e.g., obesity) is not fullyresolved. Here, we established FATTLAS, an interactive public database, for improved access and analysisof RNA-seq data of mouse and human AT. After extracting the GPCRome of non-obese and obese individuals, highly expressed and differentially regulated GPCRs were identified. Exemplarily, we describe fourreceptors (GPR146, MRGPRF, FZD5, PTGER2) and analyzed their functions in a (pre)adipocyte cell model.Besides all receptors being involved in adipogenesis, MRGPRF is essential for adipocyte viability and regulates cAMP levels, while GPR146 modulates adipocyte lipolysis via constitutive activation of Gi proteins.Taken together, by implementing and using FATTLAS we describe four hitherto unrecognized GPCRsassociated with AT function and adipogenesis.
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