TY  - JOUR
AU  - Demmert, Tristan T
AU  - Pomykala, Kelsey L
AU  - Lanzafame, Helena
AU  - Pabst, Kim M
AU  - Lueckerath, Katharina
AU  - Siveke, Jens
AU  - Umutlu, Lale
AU  - Hautzel, Hubertus
AU  - Hamacher, Rainer
AU  - Herrmann, Ken
AU  - Fendler, Wolfgang P
TI  - Oncologic Staging with 68Ga-FAPI PET/CT Demonstrates a Lower Rate of Nonspecific Lymph Node Findings Than 18F-FDG PET/CT.
JO  - Journal of nuclear medicine
VL  - 64
IS  - 12
SN  - 0097-9058
CY  - New York, NY
PB  - Soc.
M1  - DKFZ-2023-01938
SP  - 1906-1909
PY  - 2023
N1  - 2023 Dec 1;64(12):1906-1909
AB  - Nonspecific lymph node uptake on 18F-FDG PET/CT imaging is a significant pitfall for tumor staging. Fibroblast activation protein α expression on cancer-associated fibroblasts and some tumor cells is less sensitive to acute inflammatory stimuli, and fibroblast activation protein-directed PET may overcome this limitation. Methods: Eighteen patients from our prospective observational study underwent 18F-FDG and 68Ga fibroblast activation protein inhibitor (FAPI) PET/CT scans within a median of 2 d (range, 0-22 d). Lymph nodes were assessed on histopathology and compared with SUV measurements. Results: On a per-patient basis, lymph nodes were rated malignant in 10 (56
KW  - 18F-FDG PET/CT (Other)
KW  - 68Ga-FAPI PET/CT (Other)
KW  - lymph node staging (Other)
KW  - oncologic staging (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37734836
DO  - DOI:10.2967/jnumed.123.265751
UR  - https://inrepo02.dkfz.de/record/283152
ER  -