Journal Article

DKFZ-2023-01938

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Oncologic Staging with 68Ga-FAPI PET/CT Demonstrates a Lower Rate of Nonspecific Lymph Node Findings Than 18F-FDG PET/CT.

Demmert, T. T.DKFZ* ; Pomykala, K. L. ; Lanzafame, H.DKFZ* ; Pabst, K. M.DKFZ* ; Lueckerath, K.DKFZ* ; Siveke, J.DKFZ* ; Umutlu, L. ; Hautzel, H.DKFZ* ; Hamacher, R.DKFZ* ; Herrmann, K.DKFZ* ; Fendler, W. P.DKFZ*

2023
Soc. New York, NY

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Please use a persistent id in citations: doi:10.2967/jnumed.123.265751

Abstract: Nonspecific lymph node uptake on 18F-FDG PET/CT imaging is a significant pitfall for tumor staging. Fibroblast activation protein α expression on cancer-associated fibroblasts and some tumor cells is less sensitive to acute inflammatory stimuli, and fibroblast activation protein-directed PET may overcome this limitation. Methods: Eighteen patients from our prospective observational study underwent 18F-FDG and 68Ga fibroblast activation protein inhibitor (FAPI) PET/CT scans within a median of 2 d (range, 0-22 d). Lymph nodes were assessed on histopathology and compared with SUV measurements. Results: On a per-patient basis, lymph nodes were rated malignant in 10 (56%) versus 7 (39%) patients by 18F-FDG PET/CT versus 68Ga-FAPI PET/CT scans, respectively, with a respective accuracy of 55% versus 94% for true lymph node metastases. Five of 6 (83%) false-positive nodes on the 18F-FDG PET/CT scans were rated true negative by the 68Ga-FAPI PET/CT scans. On a per-lesion basis, tumor detection rates were similar (85/89 lesions, 96%). Conclusion: 68Ga-FAPI PET/CT imaging demonstrated higher accuracy for true nodal involvement and therefore has the potential to replace 18F-FDG PET/CT imaging for cancer staging.

Keyword(s): 18F-FDG PET/CT ; 68Ga-FAPI PET/CT ; lymph node staging ; oncologic staging

Note: 2023 Dec 1;64(12):1906-1909

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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