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@ARTICLE{Wimmers:284382,
      author       = {F. Wimmers$^*$ and A. R. Burrell and Y. Feng and H. Zheng
                      and P. S. Arunachalam and M. Hu and S. Spranger and L. E.
                      Nyhoff and D. Joshi and M. Trisal and M. Awasthi and L.
                      Bellusci and U. Ashraf and S. Kowli and K. C. Konvinse and
                      E. Yang and M. Blanco and K. Pellegrini and G. Tharp and T.
                      Hagan and R. S. Chinthrajah and T. T. Nguyen and A. Grifoni
                      and A. Sette and K. C. Nadeau and D. B. Haslam and S. E.
                      Bosinger and J. Wrammert and H. T. Maecker and P. J. Utz and
                      T. T. Wang and S. Khurana and P. Khatri and M. A. Staat and
                      B. Pulendran},
      title        = {{M}ulti-omics analysis of mucosal and systemic immunity to
                      {SARS}-{C}o{V}-2 after birth.},
      journal      = {Cell},
      volume       = {186},
      number       = {21},
      issn         = {0092-8674},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-01976},
      pages        = {4632-4651.e23},
      year         = {2023},
      note         = {2023 Oct 12;186(21):4632-4651.e23},
      abstract     = {The dynamics of immunity to infection in infants remain
                      obscure. Here, we used a multi-omics approach to perform a
                      longitudinal analysis of immunity to severe acute
                      respiratory syndrome coronavirus 2 (SARS-CoV-2) in infants
                      and young children by analyzing blood samples and weekly
                      nasal swabs collected before, during, and after infection
                      with Omicron and non-Omicron variants. Infection stimulated
                      robust antibody titers that, unlike in adults, showed no
                      sign of decay for up to 300 days. Infants mounted a robust
                      mucosal immune response characterized by inflammatory
                      cytokines, interferon (IFN) α, and T helper (Th) 17 and
                      neutrophil markers (interleukin [IL]-17, IL-8, and CXCL1).
                      The immune response in blood was characterized by
                      upregulation of activation markers on innate cells, no
                      inflammatory cytokines, but several chemokines and IFNα.
                      The latter correlated with viral load and expression of
                      interferon-stimulated genes (ISGs) in myeloid cells measured
                      by single-cell multi-omics. Together, these data provide a
                      snapshot of immunity to infection during the initial weeks
                      and months of life.},
      keywords     = {SARS-CoV-2 (Other) / durability (Other) / infants (Other) /
                      mucosal immunity (Other) / multi-omics (Other) / neonates
                      (Other) / single-cell ATAC-seq (Other) / single-cell RNA-seq
                      (Other) / viral infection (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37776858},
      doi          = {10.1016/j.cell.2023.08.044},
      url          = {https://inrepo02.dkfz.de/record/284382},
}