Journal Article

DKFZ-2023-01976

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth.

Wimmers, F.DKFZ* ; Burrell, A. R. ; Feng, Y. ; Zheng, H. ; Arunachalam, P. S. ; Hu, M. ; Spranger, S. ; Nyhoff, L. E. ; Joshi, D. ; Trisal, M. ; Awasthi, M. ; Bellusci, L. ; Ashraf, U. ; Kowli, S. ; Konvinse, K. C. ; Yang, E. ; Blanco, M. ; Pellegrini, K. ; Tharp, G. ; Hagan, T. ; Chinthrajah, R. S. ; Nguyen, T. T. ; Grifoni, A. ; Sette, A. ; Nadeau, K. C. ; Haslam, D. B. ; Bosinger, S. E. ; Wrammert, J. ; Maecker, H. T. ; Utz, P. J. ; Wang, T. T. ; Khurana, S. ; Khatri, P. ; Staat, M. A. ; Pulendran, B.

2023
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.cell.2023.08.044

Abstract: The dynamics of immunity to infection in infants remain obscure. Here, we used a multi-omics approach to perform a longitudinal analysis of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infants and young children by analyzing blood samples and weekly nasal swabs collected before, during, and after infection with Omicron and non-Omicron variants. Infection stimulated robust antibody titers that, unlike in adults, showed no sign of decay for up to 300 days. Infants mounted a robust mucosal immune response characterized by inflammatory cytokines, interferon (IFN) α, and T helper (Th) 17 and neutrophil markers (interleukin [IL]-17, IL-8, and CXCL1). The immune response in blood was characterized by upregulation of activation markers on innate cells, no inflammatory cytokines, but several chemokines and IFNα. The latter correlated with viral load and expression of interferon-stimulated genes (ISGs) in myeloid cells measured by single-cell multi-omics. Together, these data provide a snapshot of immunity to infection during the initial weeks and months of life.

Keyword(s): SARS-CoV-2 ; durability ; infants ; mucosal immunity ; multi-omics ; neonates ; single-cell ATAC-seq ; single-cell RNA-seq ; viral infection

Note: 2023 Oct 12;186(21):4632-4651.e23

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Tübingen (TU01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 60 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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