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@ARTICLE{SparberSauer:284983,
      author       = {M. Sparber-Sauer and M. Dietzschold and A. Schönstein and
                      A. Heinz and C. Vokuhl and K. Pajtler$^*$ and S. Harrabi$^*$
                      and Y.-L. Lin and T. v. Kalle and R. Hagen and R. Ladenstein
                      and B. Kazanowska and G. Ljungman and T. Klingebiel and M.
                      Ebinger and E. Koscielniak and M. Münter and B.
                      Timmermann$^*$},
      collaboration = {C. S. Group},
      title        = {{R}adiotherapy and long-term sequelae in pediatric patients
                      with parameningeal rhabdomyosarcoma: {R}esults of two
                      {C}ooperative {W}eichteilsarkom {S}tudiengruppe ({CWS})
                      trials and one registry.},
      journal      = {Pediatric blood $\&$ cancer},
      volume       = {71},
      number       = {1},
      issn         = {1545-5009},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-02167},
      pages        = {e30742},
      year         = {2024},
      note         = {2024 Jan;71(1):e30742},
      abstract     = {Parameningeal location of rhabdomyosarcoma (PM RMS) is
                      known to be an unfavorable prognostic factor. Scarce data
                      are available on radiotherapy (RT) concepts with regard to
                      outcome.Treatment and outcome of 395 children with PM RMS
                      registered within two Cooperative Weichteilsarkom
                      Studiengruppe (CWS) trials and one registry (1995-2021) were
                      evaluated.Patients were IRS group II (n = 15) and III (n =
                      380) and received systemic treatment according to the
                      enrolled protocols: I2VA (n = 172), VAIA/CEVAIE (n = 223).
                      Delayed resection was performed in 88/395 $(22\%)$ patients,
                      and RT was additionally given in 79/88 $(90\%)$ resected
                      patients. RT was the predominant local treatment in 355/395
                      $(90\%)$ patients: hyperfractionated accelerated photon
                      (HART; n = 77), conventionally fractionated photon (n = 91)
                      or proton beam (n = 126), brachytherapy (n = 4), heavy ions
                      (n = 1), not available (n = 56). In the subgroup of RT as
                      only local treatment (n = 278), no intracranial tumor
                      extension and complete remission at end of treatment were
                      significant positive prognostic factors. No significant
                      difference on tumor outcome was seen between different
                      radiotherapy concepts. Long-term toxicity with mostly
                      endocrinological and visual deficiencies was reported in
                      161/279 $(58\%)$ surviving patients with a lower trend after
                      proton beam RT $(48\%)$ when compared to HART or
                      conventionally fractionated photon RT $(71\%$ and $72\%,$
                      respectively). Ten-year event-free and overall survival in
                      the overall group were $62\%$ (±5, $95\%$ confidence
                      interval [CI]) and $67\%$ (±5, $95\%$ CI); in the RT-only
                      group $67\%$ (±6, $95\%$ CI) and $71\%$ (±6, $95\%$ CI),
                      respectively.CWS data confirm the recent RT concept in PM
                      RMS. Long-term sequelae as endocrinological and visual
                      deficiencies need to be addressed.},
      keywords     = {CWS Group (Other) / children and adolescents (Other) /
                      parameningeal rhabdomyosarcoma (Other) / proton beam
                      irradiation (Other)},
      cin          = {B062 / HD01 / E050 / ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)E050-20160331 / I:(DE-He78)ED01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37880926},
      doi          = {10.1002/pbc.30742},
      url          = {https://inrepo02.dkfz.de/record/284983},
}