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000285526 1001_ $$00000-0002-8237-2021$$aMorales-Berstein, Fernanda$$b0
000285526 245__ $$aUltra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis.
000285526 260__ $$aHeidelberg$$bSpringer$$c2024
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000285526 500__ $$a2024 Mar;63(2):377-396
000285526 520__ $$aTo investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome.During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14-1.34) and OAC (HR = 1.24, 95% CI 1.05-1.47). WHR mediated 5% (95% CI 3-10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6-53%) and 15% (95% CI 8-72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis.We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).
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000285526 650_7 $$2Other$$aAdiposity
000285526 650_7 $$2Other$$aEpidemiology
000285526 650_7 $$2Other$$aFood processing
000285526 650_7 $$2Other$$aHead and neck cancer
000285526 650_7 $$2Other$$aMediation analysis
000285526 650_7 $$2Other$$aNOVA classification
000285526 650_7 $$2Other$$aOesophageal cancer
000285526 7001_ $$aBiessy, Carine$$b1
000285526 7001_ $$aViallon, Vivian$$b2
000285526 7001_ $$aGoncalves-Soares, Ana$$b3
000285526 7001_ $$aCasagrande, Corinne$$b4
000285526 7001_ $$aHémon, Bertrand$$b5
000285526 7001_ $$aKliemann, Nathalie$$b6
000285526 7001_ $$aCairat, Manon$$b7
000285526 7001_ $$aBlanco Lopez, Jessica$$b8
000285526 7001_ $$aAl Nahas, Aline$$b9
000285526 7001_ $$aChang, Kiara$$b10
000285526 7001_ $$aVamos, Eszter$$b11
000285526 7001_ $$aRauber, Fernanda$$b12
000285526 7001_ $$aBertazzi Levy, Renata$$b13
000285526 7001_ $$aBarbosa Cunha, Diana$$b14
000285526 7001_ $$aJakszyn, Paula$$b15
000285526 7001_ $$aFerrari, Pietro$$b16
000285526 7001_ $$aVineis, Paolo$$b17
000285526 7001_ $$aMasala, Giovanna$$b18
000285526 7001_ $$00000-0003-2597-2060$$aCatalano, Alberto$$b19
000285526 7001_ $$aSonestedt, Emily$$b20
000285526 7001_ $$aBorné, Yan$$b21
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000285526 7001_ $$aAgnoli, Claudia$$b24
000285526 7001_ $$aGuevara, Marcela$$b25
000285526 7001_ $$aHeath, Alicia$$b26
000285526 7001_ $$aRadoï, Loredana$$b27
000285526 7001_ $$aMancini, Francesca$$b28
000285526 7001_ $$aWeiderpass, Elisabete$$b29
000285526 7001_ $$aHuerta, José María$$b30
000285526 7001_ $$aSánchez, María-José$$b31
000285526 7001_ $$aTjønneland, Anne$$b32
000285526 7001_ $$aKyrø, Cecilie$$b33
000285526 7001_ $$aSchulze, Matthias B$$b34
000285526 7001_ $$aSkeie, Guri$$b35
000285526 7001_ $$aLukic, Marko$$b36
000285526 7001_ $$aBraaten, Tonje$$b37
000285526 7001_ $$aGunter, Marc$$b38
000285526 7001_ $$aMillett, Christopher$$b39
000285526 7001_ $$aAgudo, Antonio$$b40
000285526 7001_ $$aBrennan, Paul$$b41
000285526 7001_ $$aBorges, M Carolina$$b42
000285526 7001_ $$aRichmond, Rebecca C$$b43
000285526 7001_ $$aRichardson, Tom G$$b44
000285526 7001_ $$aDavey Smith, George$$b45
000285526 7001_ $$aRelton, Caroline L$$b46
000285526 7001_ $$aHuybrechts, Inge$$b47
000285526 7001_ $$aNetwork, EPIC$$b48$$eCollaboration Author
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