Journal Article

DKFZ-2023-02406

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis.

Morales-Berstein, F. ; Biessy, C. ; Viallon, V. ; Goncalves-Soares, A. ; Casagrande, C. ; Hémon, B. ; Kliemann, N. ; Cairat, M. ; Blanco Lopez, J. ; Al Nahas, A. ; Chang, K. ; Vamos, E. ; Rauber, F. ; Bertazzi Levy, R. ; Barbosa Cunha, D. ; Jakszyn, P. ; Ferrari, P. ; Vineis, P. ; Masala, G. ; Catalano, A. ; Sonestedt, E. ; Borné, Y. ; Katzke, V.DKFZ* ; Bajracharya, R.DKFZ* ; Agnoli, C. ; Guevara, M. ; Heath, A. ; Radoï, L. ; Mancini, F. ; Weiderpass, E. ; Huerta, J. M. ; Sánchez, M.-J. ; Tjønneland, A. ; Kyrø, C. ; Schulze, M. B. ; Skeie, G. ; Lukic, M. ; Braaten, T. ; Gunter, M. ; Millett, C. ; Agudo, A. ; Brennan, P. ; Borges, M. C. ; Richmond, R. C. ; Richardson, T. G. ; Davey Smith, G. ; Relton, C. L. ; Huybrechts, I. ; Network, E. (Collaboration Author)

2024
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00394-023-03270-1

Abstract: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome.During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14-1.34) and OAC (HR = 1.24, 95% CI 1.05-1.47). WHR mediated 5% (95% CI 3-10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6-53%) and 15% (95% CI 8-72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis.We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).

Keyword(s): Adiposity ; Epidemiology ; Food processing ; Head and neck cancer ; Mediation analysis ; NOVA classification ; Oesophageal cancer

Note: 2024 Mar;63(2):377-396

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; DEAL Springer ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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