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@ARTICLE{Fontvieille:285565,
      author       = {E. Fontvieille and V. Viallon and M. Recalde and R. Cordova
                      and A. Jansana and L. Peruchet-Noray and H. Lennon and A. K.
                      Heath and D. Aune and S. Christakoudi and V. Katzke$^*$ and
                      R. Kaaks$^*$ and E. Inan-Eroglu and M. B. Schulze and L.
                      Mellemkjær and A. Tjønneland and K. Overvad and M. Farràs
                      and D. Petrova and P. Amiano and M.-D. Chirlaque and C.
                      Moreno-Iribas and S. Tin Tin and G. Masala and S. Sieri and
                      F. Ricceri and S. Panico and A. M. May and E. M. Monninkhof
                      and E. Weiderpass and M. J. Gunter and P. Ferrari and H.
                      Freisling},
      title        = {{B}ody mass index and cancer risk among adults with and
                      without cardiometabolic diseases: evidence from the {EPIC}
                      and {UK} {B}iobank prospective cohort studies.},
      journal      = {BMC medicine},
      volume       = {21},
      number       = {1},
      issn         = {1741-7015},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-02431},
      pages        = {418},
      year         = {2023},
      abstract     = {Whether cancer risk associated with a higher body mass
                      index (BMI), a surrogate measure of adiposity, differs among
                      adults with and without cardiovascular diseases (CVD) and/or
                      type 2 diabetes (T2D) is unclear. The primary aim of this
                      study was to evaluate separate and joint associations of BMI
                      and CVD/T2D with the risk of cancer.This is an individual
                      participant data meta-analysis of two prospective cohort
                      studies, the UK Biobank (UKB) and the European Prospective
                      Investigation into Cancer and nutrition (EPIC), with a total
                      of 577,343 adults, free of cancer, T2D, and CVD at
                      recruitment. We used Cox proportional hazard regressions to
                      estimate multivariable-adjusted hazard ratios (HRs) and
                      $95\%$ confidence intervals (CIs) for associations between
                      BMI and incidence of obesity-related cancer and in turn
                      overall cancer with a multiplicative interaction between BMI
                      and the two cardiometabolic diseases (CMD). HRs and $95\%$
                      CIs for separate and joint associations for categories of
                      overweight/obesity and CMD status were estimated, and
                      additive interaction was quantified through relative excess
                      risk due to interaction (RERI).In the meta-analysis of both
                      cohorts, BMI (per ~ 5 kg/m2) was positively associated with
                      the risk of obesity-related cancer among participants
                      without a CMD (HR: 1.11, $95\%CI:$ 1.07,1.16), among
                      participants with T2D (HR: 1.11, $95\%$ CI: 1.05,1.18),
                      among participants with CVD (HR: 1.17, $95\%$ CI:
                      1.11,1.24), and suggestively positive among those with both
                      T2D and CVD (HR: 1.09, $95\%$ CI: 0.94,1.25). An additive
                      interaction between obesity (BMI ≥ 30 kg/m2) and CVD with
                      the risk of overall cancer translated into a meta-analytical
                      RERI of 0.28 $(95\%$ CI: 0.09-0.47).Irrespective of CMD
                      status, higher BMI increased the risk of obesity-related
                      cancer among European adults. The additive interaction
                      between obesity and CVD suggests that obesity prevention
                      would translate into a greater cancer risk reduction among
                      population groups with CVD than among the general
                      population.},
      keywords     = {Cardiovascular diseases (Other) / Comorbidities (Other) /
                      Multimorbidity (Other) / Obesity (Other) / Obesity-related
                      cancers (Other) / Type 2 diabetes (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37993940},
      doi          = {10.1186/s12916-023-03114-z},
      url          = {https://inrepo02.dkfz.de/record/285565},
}