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000285575 1001_ $$aAbouzahr, Firas$$b0
000285575 245__ $$aThe first probe of a FLASH proton beam by PET
000285575 260__ $$aBristol$$bIOP Publ.$$c2023
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000285575 520__ $$aThe recently observed FLASH effect related to high doses delivered with high rates has the potential torevolutionize radiation cancer therapy if promising results are confirmed and an underlyingmechanism understood. Comprehensive measurements are essential to elucidate the phenomenon.We report the first-ever demonstration of measurements of successive in-spill and post-spill emissionsof gammas arising from irradiations by a FLASH proton beam. A small positron emission tomography(PET)system was exposed in an ocular beam of the Proton Therapy Center at MD Anderson CancerCenter to view phantoms irradiated by 3.5 × 1010 protons with a kinetic energy of 75.8 MeV deliveredin 101.5 ms-long spills yielding a dose rate of 164 Gy s−1. Most in-spill events were due to promptgammas. Reconstructed post-spill tomographic events, recorded for up to 20 min, yielded quantitativeimaging and dosimetric information. These findings open a new and novel modality for imaging andmonitoring of FLASH proton therapy exploiting in-spill prompt gamma imaging followed by postspill PET imaging.
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000285575 7001_ $$aCesar, John Paul$$b1
000285575 7001_ $$aCrespo, Paulo$$b2
000285575 7001_ $$aGajda, Michael Julius$$b3
000285575 7001_ $$aHu, Zongsheng$$b4
000285575 7001_ $$aKlein, Kyle$$b5
000285575 7001_ $$aKuo, Alex$$b6
000285575 7001_ $$aMajewski, Stanislaw$$b7
000285575 7001_ $$aMawlawi, Osama R$$b8
000285575 7001_ $$aMorozov, Andrey$$b9
000285575 7001_ $$aOjha, Aryan$$b10
000285575 7001_ $$aPoenisch, Falk$$b11
000285575 7001_ $$aProga, Marek$$b12
000285575 7001_ $$aSahoo, Narayan$$b13
000285575 7001_ $$0P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe$$aSeco, Joao$$b14$$udkfz
000285575 7001_ $$aTakaoka, Takeshi$$b15
000285575 7001_ $$aTavernier, Stefaan$$b16
000285575 7001_ $$aTitt, Uwe$$b17
000285575 7001_ $$aWang, Xiaochun$$b18
000285575 7001_ $$aZhu, Xiaorong Ronald$$b19
000285575 7001_ $$aLang, Karol$$b20
000285575 773__ $$0PERI:(DE-600)1473501-5$$aDOI:10.1088/1361-6560/ad0901 $$p235004$$tPhysics in medicine and biology$$v68$$x0031-9155$$y2023
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