Journal Article

DKFZ-2023-02437

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The first probe of a FLASH proton beam by PET

Abouzahr, F. ; Cesar, J. P. ; Crespo, P. ; Gajda, M. J. ; Hu, Z. ; Klein, K. ; Kuo, A. ; Majewski, S. ; Mawlawi, O. R. ; Morozov, A. ; Ojha, A. ; Poenisch, F. ; Proga, M. ; Sahoo, N. ; Seco, J.DKFZ* ; Takaoka, T. ; Tavernier, S. ; Titt, U. ; Wang, X. ; Zhu, X. R. ; Lang, K.

2023
IOP Publ. Bristol

Please use a persistent id in citations: doi:DOI:10.1088/1361-6560/ad0901

Abstract: The recently observed FLASH effect related to high doses delivered with high rates has the potential torevolutionize radiation cancer therapy if promising results are confirmed and an underlyingmechanism understood. Comprehensive measurements are essential to elucidate the phenomenon.We report the first-ever demonstration of measurements of successive in-spill and post-spill emissionsof gammas arising from irradiations by a FLASH proton beam. A small positron emission tomography(PET)system was exposed in an ocular beam of the Proton Therapy Center at MD Anderson CancerCenter to view phantoms irradiated by 3.5 × 1010 protons with a kinetic energy of 75.8 MeV deliveredin 101.5 ms-long spills yielding a dose rate of 164 Gy s−1. Most in-spill events were due to promptgammas. Reconstructed post-spill tomographic events, recorded for up to 20 min, yielded quantitativeimaging and dosimetric information. These findings open a new and novel modality for imaging andmonitoring of FLASH proton therapy exploiting in-spill prompt gamma imaging followed by postspill PET imaging.

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Contributing Institute(s):

1. E041 Med. Physik in der Radioonkologie (E041)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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