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@ARTICLE{Abouzahr:285575,
      author       = {F. Abouzahr and J. P. Cesar and P. Crespo and M. J. Gajda
                      and Z. Hu and K. Klein and A. Kuo and S. Majewski and O. R.
                      Mawlawi and A. Morozov and A. Ojha and F. Poenisch and M.
                      Proga and N. Sahoo and J. Seco$^*$ and T. Takaoka and S.
                      Tavernier and U. Titt and X. Wang and X. R. Zhu and K. Lang},
      title        = {{T}he first probe of a {FLASH} proton beam by {PET}},
      journal      = {Physics in medicine and biology},
      volume       = {68},
      issn         = {0031-9155},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {DKFZ-2023-02437},
      pages        = {235004},
      year         = {2023},
      abstract     = {The recently observed FLASH effect related to high doses
                      delivered with high rates has the potential torevolutionize
                      radiation cancer therapy if promising results are confirmed
                      and an underlyingmechanism understood. Comprehensive
                      measurements are essential to elucidate the phenomenon.We
                      report the first-ever demonstration of measurements of
                      successive in-spill and post-spill emissionsof gammas
                      arising from irradiations by a FLASH proton beam. A small
                      positron emission tomography(PET)system was exposed in an
                      ocular beam of the Proton Therapy Center at MD Anderson
                      CancerCenter to view phantoms irradiated by 3.5 × 1010
                      protons with a kinetic energy of 75.8 MeV deliveredin 101.5
                      ms-long spills yielding a dose rate of 164 Gy s−1. Most
                      in-spill events were due to promptgammas. Reconstructed
                      post-spill tomographic events, recorded for up to 20 min,
                      yielded quantitativeimaging and dosimetric information.
                      These findings open a new and novel modality for imaging
                      andmonitoring of FLASH proton therapy exploiting in-spill
                      prompt gamma imaging followed by postspill PET imaging.},
      cin          = {E041},
      ddc          = {530},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      doi          = {DOI:10.1088/1361-6560/ad0901 },
      url          = {https://inrepo02.dkfz.de/record/285575},
}