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000286195 1001_ $$00000-0001-9229-2589$$aWatts, Eleanor L$$b0
000286195 245__ $$aObservational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study.
000286195 260__ $$aEdinburgh$$bNature Publ. Group$$c2024
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000286195 520__ $$aThe association of fitness with cancer risk is not clear.We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method.After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O2⋅min-1⋅kg-1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR = 0.81, 95% CI: 0.73-0.89), colorectal (0.94, 0.90-0.99), and breast cancer (0.96, 0.92-0.99). In MR analyses, a 0.5 SD increase in genetically predicted O2⋅min-1⋅kg-1 fat-free mass was associated with a lower risk of breast cancer (OR = 0.92, 95% CI: 0.86-0.98). After adjusting for adiposity, both the observational and genetic associations were attenuated.Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Increasing fitness, including via changes in body composition, may be an effective strategy for cancer prevention.
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000286195 7001_ $$00000-0003-0085-8771$$aGonzales, Tomas I$$b1
000286195 7001_ $$aStrain, Tessa$$b2
000286195 7001_ $$aSaint-Maurice, Pedro F$$b3
000286195 7001_ $$00000-0002-8752-8785$$aBishop, D Timothy$$b4
000286195 7001_ $$aChanock, Stephen J$$b5
000286195 7001_ $$00000-0002-3116-5081$$aJohansson, Mattias$$b6
000286195 7001_ $$aKeku, Temitope O$$b7
000286195 7001_ $$aLe Marchand, Loic$$b8
000286195 7001_ $$00000-0002-2818-5487$$aMoreno, Victor$$b9
000286195 7001_ $$00000-0001-8786-0043$$aNewcomb, Polly A$$b10
000286195 7001_ $$aNewton, Christina C$$b11
000286195 7001_ $$aPai, Rish K$$b12
000286195 7001_ $$aPurdue, Mark P$$b13
000286195 7001_ $$aUlrich, Cornelia M$$b14
000286195 7001_ $$aSmith-Byrne, Karl$$b15
000286195 7001_ $$aVan Guelpen, Bethany$$b16
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000286195 7001_ $$00000-0003-3789-7651$$aDay, Felix R$$b18
000286195 7001_ $$aWijndaele, Katrien$$b19
000286195 7001_ $$00000-0003-1422-2993$$aWareham, Nicholas J$$b20
000286195 7001_ $$aMatthews, Charles E$$b21
000286195 7001_ $$aMoore, Steven C$$b22
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