Journal Article

DKFZ-2023-02699

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study.

Watts, E. L. ; Gonzales, T. I. ; Strain, T. ; Saint-Maurice, P. F. ; Bishop, D. T. ; Chanock, S. J. ; Johansson, M. ; Keku, T. O. ; Le Marchand, L. ; Moreno, V. ; Newcomb, P. A. ; Newton, C. C. ; Pai, R. K. ; Purdue, M. P. ; Ulrich, C. M. ; Smith-Byrne, K. ; Van Guelpen, B. ; PRACTICAL consortium, C. (Collaboration Author) ; Day, F. R. ; Wijndaele, K. ; Wareham, N. J. ; Matthews, C. E. ; Moore, S. C. ; Brage, S. ; Eeles, R. A. (Contributor) ; Haiman, C. A. (Contributor) ; Kote-Jarai, Z. (Contributor) ; Schumacher, F. R. (Contributor) ; Benlloch, S. (Contributor) ; Olama, A. A. A. (Contributor) ; Muir, K. R. (Contributor) ; Berndt, S. I. (Contributor) ; Conti, D. V. (Contributor) ; Wiklund, F. (Contributor) ; Chanock, S. J. (Contributor) ; Wang, Y. (Contributor) ; Tangen, C. M. (Contributor) ; Batra, J. (Contributor) ; Clements, J. A. (Contributor) ; Grönberg, H. (Contributor) ; Pashayan, N. (Contributor) ; Schleutker, J. (Contributor) ; Albanes, D. (Contributor) ; Weinstein, S. J. (Contributor) ; Wolk, A. (Contributor) ; West, C. M. L. (Contributor) ; Mucci, L. A. (Contributor) ; Cancel-Tassin, G. (Contributor) ; Koutros, S. (Contributor) ; Sørensen, K. D. (Contributor) ; Grindedal, E. M. (Contributor) ; Neal, D. E. (Contributor) ; Hamdy, F. C. (Contributor) ; Donovan, J. L. (Contributor) ; Travis, R. C. (Contributor) ; Hamilton, R. J. (Contributor) ; Ingles, S. A. (Contributor) ; Rosenstein, B. S. (Contributor) ; Lu, Y.-J. (Contributor) ; Giles, G. G. (Contributor) ; MacInnis, R. J. (Contributor) ; Kibel, A. S. (Contributor) ; Vega, A. (Contributor) ; Kogevinas, M. (Contributor) ; Penney, K. L. (Contributor) ; Park, J. Y. (Contributor) ; Stanford, J. L. (Contributor) ; Cybulski, C. (Contributor) ; Nordestgaard, B. G. (Contributor) ; Nielsen, S. F. (Contributor) ; Brenner, H. (Contributor)DKFZ* ; Maier, C. (Contributor) ; Kim, J. (Contributor) ; John, E. M. (Contributor) ; Teixeira, M. R. (Contributor) ; Neuhausen, S. L. (Contributor) ; De Ruyck, K. (Contributor) ; Razack, A. (Contributor) ; Newcomb, L. F. (Contributor) ; Lessel, D. (Contributor) ; Kaneva, R. (Contributor) ; Usmani, N. (Contributor) ; Claessens, F. (Contributor) ; Townsend, P. A. (Contributor) ; Castelao, J. E. (Contributor) ; Roobol, M. J. (Contributor) ; Menegaux, F. (Contributor) ; Khaw, K.-T. (Contributor) ; Cannon-Albright, L. (Contributor) ; Pandha, H. (Contributor) ; Thibodeau, S. N. (Contributor) ; Hunter, D. J. (Contributor) ; Kraft, P. (Contributor) ; Blot, W. J. (Contributor) ; Riboli, E. (Contributor)

2024
Nature Publ. Group Edinburgh

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Please use a persistent id in citations: doi:10.1038/s41416-023-02489-3

Abstract: The association of fitness with cancer risk is not clear.We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method.After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O2⋅min-1⋅kg-1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR = 0.81, 95% CI: 0.73-0.89), colorectal (0.94, 0.90-0.99), and breast cancer (0.96, 0.92-0.99). In MR analyses, a 0.5 SD increase in genetically predicted O2⋅min-1⋅kg-1 fat-free mass was associated with a lower risk of breast cancer (OR = 0.92, 95% CI: 0.86-0.98). After adjusting for adiposity, both the observational and genetic associations were attenuated.Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Increasing fitness, including via changes in body composition, may be an effective strategy for cancer prevention.

Note: 2024 Jan;130(1):114-124

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. Präventive Onkologie (C120)
3. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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